Identification

Description


Numéro UN : UN2281

Formule moléculaire brute : C8H12N2O2

Principaux synonymes

Noms français :

  • 1,6-DIISOCYANATOHEXANE
  • 1,6-HEXAMETHYLENE DIISOCYANATE
  • 1,6-HEXANEDIOL DIISOCYANATE
  • Diisocyanate d'hexaméthylène
  • DIISOCYANATE-1,6 D'HEXAMETHYLENE
  • DIISOCYANATE-1,6 D'HEXANE NORMAL
  • HDI
  • HEXAMETHYLENE-1,6-DIISOCYANATE
  • Hexamethylenediisocyanate
  • HEXANE, 1,6-DIISOCYANATO-
  • HEXANE-1,6-DIISOCYANATE
  • ISOCYANIC ACID, DIESTER WITH 1,6-HEXANEDIOL
  • ISOCYANIC ACID, HEXAMETHYLENE ESTER

Noms anglais :

  • Hexamethylene diisocyanate
Utilisation et sources d'émission

Fabrication de produit organique et de peinture

Références

  • ▲1.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/t-06.pdf
  • ▲2.  Truchon, G., Guide de surveillance biologique : prélèvement et interprétation des résultats. Études et recherches / IRSST, 5ème éd. Montréal : IRSST. (1999). T-03.   http://www.irsst.qc.ca http://www.irsst.qc.ca/media/documents/pubirsst/t-03.pdf
  • ▲3.  Règlement sur la santé et la sécurité du travail [S-2.1, r. 13]. Québec : Éditeur officiel du Québec. [RJ-510071]   http://legisquebec.gouv.qc.ca/fr/ShowDoc/cr/S-2.1,%20r.%2013
  • ▲4.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  • ▲5.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲5.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲6.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 162 : 1,6-Diisocyanate d'hexaméthylène. Cahiers de notes documentaires. Paris : INRS. (2000). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_162
  • ▲6.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 162 : 1,6-Diisocyanate d'hexaméthylène. Cahiers de notes documentaires. Paris : INRS. (2000). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_162
  • ▲7.  Agency for Toxic Substances and Disease Registry, Toxicological profile for hexamethylene diisocyanate. Atlanta, GA : ATSDR. (1998).   https://www.atsdr.cdc.gov/ToxProfiles/tp120.pdf
    http://www.atsdr.cdc.gov/toxprofiles/
  • ▲8.  OECD, «Hexamethylene diisocyanate CAS N°: 822-06-0.» In: OECD Screening Information Data Set (SIDS) for High Production Volume Chemicals. Paris : UNEP Publications. (2001).   http://www.inchem.org/documents/sids/sids/822060.pdf
  • ▲9.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲9.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲10.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 1, 4th ed. Springfield (ILL.) : Charles C. Thomas. (1993). [RM-515030]
  • ▲11.  Bernstein, D. et al., Asthma in the workplace. 2nd ed. New York : Marcel Dekker. (1999 ).
  • ▲12.  Lundberg, P., Scientific basis for swedish occupational standards X . Arbete och Hälsa 1989:32. Solna, Suède : Arbetslivinstituet. (1989). [MO-011239]   https://gupea.ub.gu.se/dspace/handle/2077/3194?locale=en
  • ▲13.  Gadon, M.E. et al., «New-onset asthma after exposure to the steam system additive 2-diethylaminoethanol. A descriptive study.» Journal of Occupational Medicine. Vol. 36, no. 6, p. 623-626. (1994). [AP-045220]
  • ▲14.  American Conference of Governmental Industrial Hygienists, «Hexamethylene diisocyanate.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2001). Publication #0100Doc.   http://www.acgih.org
  • ▲15.  Musk, A.W., Peters, J.M. et Wegman, D.H., «Isocyanates and Respiratory Disease: Current Status.» American Journal of Industrial Medicine. Vol. 13, p. 331-349. (1988). [AP-017495]
  • ▲16.  Estlander, T. et al., «Occupational dermatitis from exposure to polyurethane chemicals.» Contact dermatitis. Vol. 27, p. 161-165. (1992).
  • ▲17.  Clemmensen, S., «Cross-reaction patterns in guinea pigs sensitized to acrylic monomers.» Drug and Chemical Toxicology. Vol. 7, no. 6, p. 527-540. (1984).
  • ▲18.  Gad, S.C. et al., «Development and validation of an alternative dermal sensitization test : the mouse er swelling test (MEST).» Toxicology and Applied Pharmacology. Vol. 84, p. 93-114. (1986). [AP-019707 ]
  • ▲19.  Karol, M.H. et Kramarik, J.A., «Phenyl isocyanate is a potent chemical sensitizer.» Toxicology Letters. Vol. 89, p. 139-146. (1996). [AP-051636]
  • ▲20.  Basketter, D.A. et Gerberick, G.F., «An interlaboratory evaluation of the Buehler test for the identification and classification of skin sensitizers.» Contact Dermatitis. Vol. 35, no. 3, p. 146-151. (1996).
  • ▲21.  Malo, J.-L., Chang-Yeung, M. et Bernstein, D.I., Asthma in the workplace. 4th ed. New York : CRC Press / Taylor @ Francis Group. (2013). [MO-002878]   http://www.taylorandfrancis.com
    http://www.crcpress.com
  • ▲22.  Wilkinson S.M. et al., «Allergic Contact Dermatitis From 1,6-diisocyanatohexane in an Anti-pill Finish.» Contact Dermatitis. Vol. 25, p. 94-96. (1991). [AP-035867]
  • ▲23.  Goossens A., Detienne T. et Bruze M., «Occupational Allergic Contact Dermatitis Caused by Isocyanates..» Contact Dermatitis. Vol. 47, no. 5, p. 304-308. (2002).
  • ▲24.  Zissu D., Binet S. et Limasser J.C., «Cutaneous Sensitization to Some Polyisocyanate Prepolymers in Guinea Pigs..» Contact Dermatitis. Vol. 39, no. 5, p. 248-251. (1998).
  • ▲25.  Malo, J.-L. et al., «Combined alveolitis and asthma due to hexamethylene diisocyanate (HDI), with demonstration of crossed respiratory and immunologic reactivities to diphenylmethane diisocyanate (MDI).» Journal of Allergy and Clinical Immunology. [AP-124610]
  • ▲26.  Criteria Group for Occupationnal Standards, «Scientific Basis for Swedish Occupational Standards XXII : Consensus Report for Toluene Diisocyanate (TDI), Diphenylmethane Diisocyanate (MDI), 60 Hexamethylene Diisocyanate (HDI).» Arbete och Hälsa. Vol. 20, p. 60-80. (2001).   http://www.inchem.org/documents/kemi/kemi/ah2001_20.pdf
  • ▲27.  Astroff, A. B. et al., «A combined reproduction, neonatal development, and neurotoxicity study with 1,6-hexamethylene diisocyanate (HDI) in the rat.» Reproductive Toxicology. Vol. 14, no. 2, p. 135-146. (2000).
  • ▲28.  Agency for Toxic Substances and Disease Registry, Toxicological profile for hexamethylene diisocyanate. Atlanta, GA : ATSDR. (1998). Microfiche : PB99-102543   http://www.atsdr.cdc.gov/toxprofiles/
  • ▲29.  Shiotsuka, R.N. et Mobay Corporation, Chronic Inhalation Toxicity and Oncogenicity Study with 1,6-Hexamethylene Diisocyanate (HDI) in Rats (Final Report) with Attached Appendices and Cover Letter Dated 122089. Stilwell, Kansas. (1989). Microfiche : OTS0521604, 86900000055
  • ▲30.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲31.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
    http://www.tc.gc.ca/tmd/menu.htm

Autres sources d'information

  • Smyth, H.F., Carpenter, C.P. et Weil, C.S., «Range-Finding Toxicity Data : List VII.» American Industrial Hygiene Association Journal. Vol. 30, no. 5, p. 470-476. (1969). [AP-000464]
  • BRITISH JOURNAL OF DISEASES OF THE CHEST, VOL. 81, 1987, P. 14-22 [AP-018787]
  • Malo, J.-L. et al., «Combined alveolitis and asthma due to hexamethylene diisocyanate (HDI), with demonstration of crossed respiratory and immunologic reactivities to diphenylmethane diisocyanate (MDI).» Journal of Allergy and Clinical Immunology. [AP-124610]
  • Thorne, P.S. et al., «Contact sensitivity by diisocyanates : potencies and cross-reactivities.» Toxicology and Applied Pharmacology. Vol. 87, no. 1, p. 155-165. (1987). [AP-136314]
  • Toxicology and Applied Pharmacology, VOL. 57, 1981, P. 241-246 [AP-009125]
  • CANCER RESEARCH, VOL. 31, 1971, P. 937-941 [AP-025209]
  • MEDICINA DEL LAVORO, VOL. 77, NO 2, 1986, P. 191-194 [AP-134861]
  • SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT AND HEALTH, VOL. 7, 1981, P. 310-311 [AP-160141]
  • Archives of Environmental Health, VOL. 42, NO 6, 1987, P. 367-373 [AP-017653]
  • Clinical Allergy, VOL. 9, 1979, P. 1-6 [AP-020083]
  • Pathogenesis of occupationally-induced isocyanate reactions., 1981 Microfiche : PB88-247283

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