Isoflurane

Numéro CAS : 26675-46-7

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  • PMSD
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  • Résumé

L'information disponible sur cette substance est partielle. Pour de plus amples renseignements, veuillez communiquer avec le Répertoire toxicologique.

Identification

Description


Formule moléculaire brute : C3H2ClF5O

Principaux synonymes

Noms français :

  • Chloro-2 difluorométhoxy-2 trifluoro-1,1,1 éthane
  • Isoflurane

Noms anglais :

  • 1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether
  • Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-
  • Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl-
Utilisation et sources d'émission

Agent anesthésiant

Références

  • ▲1.  Giroud, J.-P., Mathé, G. et Meyniel, G., Pharmacologie clinique : bases de la thérapeutique. 2e éd. Paris : Expansion Scientifique Française. (1988). [RM-414008]
  • ▲2.  Dale, O. et Brown, B.R., «Clinical pharmacokinetics of the inhalational anaesthetics.» Clinical Pharmacokinetics. Vol. 12, p. 145-167. (1987).
  • ▲3.  Munson, E.S., «Isoflurane.» Middle East J. Anaesthesiol. . Vol. 6, no. 4, p. 181-188. (1982).
  • ▲4.  Fiserova-Bergerova, V. et Holaday, D.A., «Uptake and clearance of inhalation anesthetics in man.» Drug Metabolism Reviews. Vol. 9, no. 1, p. 43-60. (1979).
  • ▲5.  Wissing, H. et al., «Pharmacokinetics of inhaled anaesthetics in a clinical setting : comparison of desflurane, isoflurane and sevoflurane.» British Journal of Anaesthesia. Vol. 84, p. 443-449. (2000).
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  • ▲9.  Waskell, L., Metabolism of the volatile anesthetics. New York : Raven Press. (1994).
  • ▲10.  McDougal, J.N. et al., «Dermal absorption of organic chemical vapors in rats and humans .» Fundamental and Applied Toxicology. Vol. 14, p. 299-308. (1990). [AP-026900]
  • ▲11.  Van Dyke, R.A., Toxic metabolites from biotransformation : major organ damage. International Anesthesiology Clinics, Vol. 19. Boston : Little, Brown and Company. (1981).
  • ▲12.  Lockhart, S.H. et al., «Comparison of percutaneous losses of sevoflurane and isoflurane in humans.» Anesthesia and Analgesia. Vol. 72, p. 212-215. (1991).
  • ▲13.  Vellore, A.D. et al., «Occupational asthma and allergy to sevoflurane and isoflurane in anaesthetic staff.» Allergy. Vol. 61, no. 12, p. 1485-1486. (2006).
  • ▲14.  Finch, T.M. et al., «Occupational airborne allergic contact dermatitis from isoflurane vapour.» Contact Dermatitis. Vol. 42, no. 1, p. 46. (2000).
  • ▲15.  Caraffini, S. et al., «Isoflurance : an uncommon cause of occupational airborne contact dermatitis.» Contact Dermatitis. Vol. 38, no. 5, p. 286. (1998).
  • ▲16.  Mazze, R.I. et al., «Reproductive and teratogenic effects of nitrous oxide, halothane, isoflurane, and enflurane in Sprague-Dawley rats.» Anesthesiology. Vol. 64, p. 339-344. (1986).
  • ▲17.  Dwyer, R., «Uptake of halothane and isoflurane by mother and baby during Caesarean section.» British Journal of Anaesthesia. Vol. 74, p. 379 - 383. (1995). [AP-058418]
  • ▲18.  Mazze, R.I. et al., «Fetal development in mice exposed to isoflurane.» Teratology. Vol. 32, no. 3, p. 339-345. (1985).
  • ▲19.  Kennedy, G.L. et al., «Reproductive and teratologic studies with isoflurane.» Drug and Chemical Toxicology. Vol. 1, no. 1, p. 75-88. (1977-78). [AP-058425]
  • ▲20.  Fujinaga, M. et al., «Reproductive and teratogenic effects of nitrous oxide, isoflurane, and their combination in Sprague-Dawley rats.» Anesthesiology. Vol. 67, p. 960-964. (1987).
  • ▲21.  Rice, S.A., «Behavioral effects of in utero isoflurane exposure in young SW mice.» Teratology. Vol. 33, no. 3, p. 100C-101C. (1986). [AP-040224]
  • ▲22.  Fisher, J. et al., «Lactational transfer of volatile chemicals in breast milk.» American Industrial Hygiene Association Journal. Vol. 58, no. 6, p. 425-431. (1997). [AP-051996]
  • ▲23.  Preib, A. et al., «The determination of trifluoroacetic acid in rat milk samples by 19F-NMR spectroscopy and capillary gas chromatography.» Journal of Pharmaceutical and Biochemical Analysis. Vol. 16, p. 1381-1385. (1998).
  • ▲24.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Overall evaluations of carcinogenicity : an updating of IARC monographs volumes 1-42. IARC monographs on the evaluation of carcinogenic risks to humans, Supplement 7. Lyon : International Agency for Research on Cancer. (1987).   https://monographs.iarc.fr/wp-content/uploads/2018/06/Suppl7.pdf
    http://monographs.iarc.fr/
  • ▲25.  IARC Working Group on the Evaluation of Carcinogenic Risks of Chemical to Man, Cadmium, nickel, some epoxides, miscellaneous industrial chemicals and general considerations on volatile anaesthetics. IARC monographs on the evaluation of carcinogenic risks of chemical to man, Vol. 11. Lyon : International Agency for Research on Cancer. (1976).  

    https://monographs.iarc.fr/wp-content/uploads/2018/06/mono11.pdf

    http://www.iarc.fr


  • ▲26.  Eger, E.I. et al., «A test of the carcinogenicity of enflurane, isoflurane, halothane, methoxyflurane, and nitrous oxide in mice.» Anesthesia and Analgesia. Vol. 57, p. 678-694. (1978).
  • ▲27.  Corbett, T.H., «Cancer and congenital anomalies associated with anesthetics.» Annals of the New York Academy of Sciences. Vol. 271, p. 58-66. (1976).
  • ▲28.  Baden, J.M. et al., «Carcinogen bioassay of isoflurane in mice.» Anesthesiology. Vol. 69, p. 750-753. (1988).
  • ▲29.  Robbiano, L. et al., «Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics.» Mutation Research. Vol. 413, p. 1-6. (1998).
  • ▲30.  White, A.E. et al., «Sister chromatid exchanges induced by inhaled anesthetics.» Anesthesiology. Vol. 50, p. 426-430. (1979).
  • ▲31.  Trudnowski, R.J., Mehta, M.P. et Rucinski, M., «Evaluation of the mutagenic potential of enflurane and isoflurane by sister chromatid exchange.» Journal of Medicine. Vol. 18, no. 1, p. 55-60. (1987).
  • ▲32.  Hoerauf, K.H. et al., «Sister chromatid exchange in human lymphocytes exposed to isoflurane and nitrous oxide in vitro.» British Journal of Anaesthesia. Vol. 82, no. 2, p. 268-270. (1999).
  • ▲33.  Jaloszynski, P. et al., «Genotoxicity of inhalation anesthetics halothane and isoflurane in human lymphocytes studied in vitro using comet assay.» Mutation Research. Vol. 439, p. 199-206. (1999).

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