L'information disponible sur cette substance est partielle. Pour de plus amples renseignements, veuillez communiquer avec le Répertoire toxicologique.

Identification

Description


Formule moléculaire brute : C8H6O2

Principaux synonymes

Noms français :

  • 1,2-Benzene dicarbonal
  • 1,2-BENZENEDICARBOXALDEHYDE
  • ALDEHYDE ORTHO-PHTALIQUE
  • o-Phtaldialdéhyde
  • O-PHTHALDEHYDE
  • ortho-Phtalaldéhyde
  • ortho-phthalaldehyde
  • ORTHOPHTHALDIALDEHYDE
  • PHTALALDEHYDE (ORTHO-)
  • PHTHALIC O-DICARBOXALDEHYDE

Noms anglais :

  • o-Phthalaldehyde
  • o-Phthalic aldehyde
Commentaires

L'ortho-phtalaldéhyde pur est rarement rencontré dans le milieu de travail. Lorsqu'il est utilisé comme désinfectant, il se présente sous forme de solution aqueuse dont la concentration est d'environ 0,55 %. Les solutions commerciales contiennent des additifs qui permettent d'en stabiliser le pH, tels que l'acide citrique et les phosphates, des agents de conservation et des colorants.

Utilisation et sources d'émission 1 2 3 4 5 6

L'ortho-phtalaldéhyde est surtout utilisé comme désinfectant chimique à haute efficacité pour des instruments dentaires ou médicaux, comme les endoscopes. Il est souvent considéré comme une alternative plus sécuritaire au glutaraldéhyde.

Il est également employé en laboratoire, comme réactif pour les analyses fluorométriques d'amines primaires et de thiols.

Références

  • ▲1.  National Industrial Chemicals Notification and Assessment Scheme, Ortho-Phthalaldehyde. Existing Chemicals Information Sheet. Canberra, Australia : NICNAS. (2005).   http://www.nicnas.gov.au/publications/CAR.asp
    http://www.nicnas.gov.au/industry/existing_chemicals/screening_results/ec_ortho-phthalaldehyde.pdf
  • ▲1.  National Industrial Chemicals Notification and Assessment Scheme, Ortho-Phthalaldehyde. Existing Chemicals Information Sheet. Canberra, Australia : NICNAS. (2005).   http://www.nicnas.gov.au/publications/CAR.asp
    http://www.nicnas.gov.au/industry/existing_chemicals/screening_results/ec_ortho-phthalaldehyde.pdf
  • ▲2.  Rideout, K.L., Evaluating occupational health risks associated with substitution of high-level disinfectants in hospitals. Master of science in the faculty of graduate studies. British Columbia : The University of British Columbia. (2003).   http://www.cher.ubc.ca/PDFs/hospdisinfectantsfull.pdf
  • ▲2.  Rideout, K.L., Evaluating occupational health risks associated with substitution of high-level disinfectants in hospitals. Master of science in the faculty of graduate studies. British Columbia : The University of British Columbia. (2003).   http://www.cher.ubc.ca/PDFs/hospdisinfectantsfull.pdf
  • ▲2.  Rideout, K.L., Evaluating occupational health risks associated with substitution of high-level disinfectants in hospitals. Master of science in the faculty of graduate studies. British Columbia : The University of British Columbia. (2003).   http://www.cher.ubc.ca/PDFs/hospdisinfectantsfull.pdf
  • ▲3.  Pala, G. et Moscato, G., «Allergy to ortho-phthalaldehyde in the healthcare setting : advice for clinicians .» Expert Rev. Clin. Immunol. Vol. 9, no. 3, p. 227-234. (2013).
  • ▲3.  Pala, G. et Moscato, G., «Allergy to ortho-phthalaldehyde in the healthcare setting : advice for clinicians .» Expert Rev. Clin. Immunol. Vol. 9, no. 3, p. 227-234. (2013).
  • ▲4.  O'Neil, M.J. et al., The Merck Index : an encyclopedia of chemicals, drugs, & biologicals. 15e éd. Cambridge, G.-B. : Royal Society of Chemistry. (2013). [RM-403001]   https://www.rsc.org/Merck-Index/
  • ▲5.  Catlin, N. et al., «Evaluation of the respiratory tract toxicity of ortho-phthalaldehyde, a proposed alternative for the chemical disinfectant glutaraldehyde.» Inhalation toxicology. Vol. 29, no. 9, p. 414-427. (2017). [AP-001165]
  • ▲5.  Catlin, N. et al., «Evaluation of the respiratory tract toxicity of ortho-phthalaldehyde, a proposed alternative for the chemical disinfectant glutaraldehyde.» Inhalation toxicology. Vol. 29, no. 9, p. 414-427. (2017). [AP-001165]
  • ▲6.  Morinaga, T. et al., «Acute inflammation and immunoresponses induced by ortho-phthalaldehyde in mice.» Archives of toxicology. Vol. 84, no. 5, p. 397-404. (May 2010). [AP-001168]
  • ▲7.  Lenga, R.E., The Sigma-Aldrich library of chemical safety data. 2nd ed. Milwaukee : Sigma-Aldrich. (1988).
  • ▲8.  Johnson & Johnson Medical, Executive summary. Toxicological data for ortho-phthalaldehyde (OPA) (1,2-benzenedicarboxaldehyde).
  • ▲8.  Johnson & Johnson Medical, Executive summary. Toxicological data for ortho-phthalaldehyde (OPA) (1,2-benzenedicarboxaldehyde).
  • ▲9.  Andrés-López, B., Lleonart, R. et Corominas, M., «Hypersensitivity to Cidex OPA : a misdiagnosed condition.» Journal of allergy and clinical immunology. In practice. Vol. 4, no. 6, p. 1260-1261. (Nov.-Dec. 2016). [AP-001166]
  • ▲10.  U.S. Department of Health and Human Services, NTP Technical Report on the Toxicity Studies of o-Phthalaldehyde (CAS No. 643-79-8) administred by inhalation to Sprague Dawley Rats and B6C3F1/N Mice. Toxicity Report Series, Number 84. Research Triangle Park, NC : U.S. National Toxicology Program. (2018).   https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox084_508.pdf
  • ▲10.  U.S. Department of Health and Human Services, NTP Technical Report on the Toxicity Studies of o-Phthalaldehyde (CAS No. 643-79-8) administred by inhalation to Sprague Dawley Rats and B6C3F1/N Mice. Toxicity Report Series, Number 84. Research Triangle Park, NC : U.S. National Toxicology Program. (2018).   https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox084_508.pdf
  • ▲11.  Service de l'Environnement, de la Santé et de la Sécurité de J.T.Baker, Material Safety Data Sheet o-phtalaldéhyde. Phillipsburg, NJ : J.T.Baker. (2004).   http://www.jtbaker.com/msds/frenchhtml/P4230.htm
  • ▲13.  Johnson V.J., Reynolds J.S. et Wang W., «Inhalation of Ortho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice.» Journal of Allergy. (2011). Article ID 751052.   https://www.hindawi.com/journals/ja/2011/751052/
  • ▲14.  Health and Safety Executive (HSE), «Appendix 1 : Watch paper on succinic dialdehyde & o-phthalaldehyde.» In: Endoscope disinfection - alternatives to glutaraldehyde. Grande-Bretagne. (2003). SIM 07/2003/14.   http://www.hse.gov.uk/foi/internalops/sectors/public/
    http://www.hse.gov.uk/foi/internalops/sectors/public/7_03_14.pdf
  • ▲15.  Cooke R,P.D. et al., «An evaluation of Cidex OPA (0,55 % ortho-phthalaldehyde) as an alternative to 2 % glutaraldehyde for high-level disinfection of endoscopes.» Journal of Hospital Infection. Vol. 54, no. 3, p. 226-231. (2003).   http://www.sciencedirect.com
  • ▲16.  Chen L. et al., Health Hazard Evaluation Program: Evaluation of Ortho-phthalaldehyde in Eight Healthcare Facilities. Cincinnati, OH : U.S. National Institute for Occupational Safety and Health. (2015). HHE Report No. 2006-0238-3239.   https://www.cdc.gov/niosh/hhe/reports/pdfs/2006-0238-3239.pdf
  • ▲17.  Franchi, A. et Franco, G., «Evidence-based decision making in an endoscopy nurse with respiratory symptoms exposed to the new ortho-phthalaldehyde (OPA) disinfectant.» Occupational Medicine. Vol. 55, p. 575-578. (2005).
  • ▲18.  Sokol, W.N., «Nine episodes of anaphylaxis following cystoscopy caused by Cidex OPA (ortho-phthlaldehyde) high-level disinfectant in 4 patients after cytoscopy.» Journal of Allergy and Clinical Immunology. Vol. 114, no. 2, p. 392-397. (2004).
  • ▲19.  Rideout, K. et al., «Considering risks to healthcare workers from glutaraldehyde alternatives in high-level disinfection.» Journal of Hospital Infection. Vol. 59, p. 4-11. (2005). [AP-066350]   http://www.trudeaufoundation.ca/pdf/RideoutJournalHospitalInfection.pdf

La cote entre [ ] provient de la banque Information SST du Centre de documentation de la CNESST.