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Identification

Description


Numéro UN : UN2579

Formule moléculaire brute : C4H10N2

Principaux synonymes

Noms français :

  • 1,4-DIAZACYCLOHEXANE
  • 1,4-DIETHYLENEDIAMINE
  • 1,4-PIPERAZINE
  • DIAZA-1,4 CYCLOHEXANE
  • DIETHYLENE-1,4 DIAMINE
  • DIETHYLENEDIAMINE
  • DIETHYLENEIMINE
  • Diéthylènediamine
  • HEXAHYDRO-1,4-DIAZINE
  • N,N-DIETHYLENE DIAMINE
  • N,N-DIETHYLENEDIAMINE
  • Pipérazine

Noms anglais :

  • HEXAHYDROPYRAZINE
  • PIPERAZIDINE
  • Piperazine
  • Piperazine and salts, as piperazine
  • PIPERAZINE ANHYDROUS
  • PIPERAZINE, ANHYDROUS
  • PYRAZINE HEXAHYDRIDE
  • PYRAZINE, HEXAHYDRO-
Utilisation et sources d'émission 1 2 3

La pipérazine est utilisée comme intermédiaire pour fabriquer plusieurs produits pharmaceutiques, fibres, polymères et insecticides. Elle peut aussi être utilisée pour le traitement des vers parasites.

Références

  • ▲1.  Pohanish, R., Sittig's handbook of toxic and hazardous chemicals and carcinogens. 4ème éd. Norwich (NY) : Noyes Publications. (2002). 2 v.
  • ▲2.  Patnaik, P., A comprehensive guide to the hazardous properties of chemical substances. 3nd ed. New York : Wiley. (2007). [RM-515120]
  • ▲3.  American Conference of Governmental Industrial Hygienists, «Piperazine and Salts.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2014). Publication #0100Doc.   http://www.acgih.org
  • ▲3.  American Conference of Governmental Industrial Hygienists, «Piperazine and Salts.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2014). Publication #0100Doc.   http://www.acgih.org
  • ▲3.  American Conference of Governmental Industrial Hygienists, «Piperazine and Salts.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2014). Publication #0100Doc.   http://www.acgih.org
  • ▲4.  Lewis Sr., R.J., Hazardous chemicals desk reference. 6 éd. Hoboken (New Jersey) : John Wiley & Sons Inc. (2008). [RM-515053]   www.wiley.com
  • ▲5.  Pohanish, R.P. et Greene, S.A., Hazardous materials handbook. New York (NY) : Van Nostrand Reinhold. (1996). [RR-515125]
  • ▲6.  Pohanish, R.P., Sittig's handbook of toxic and hazardous chemicals and carcinogens. 6th ed. Amsterdam : William Andrew. (2012). [RR-015003]   https://www.sciencedirect.com/book/9781437778694/sittigs-handbook-of-toxic-and-hazardous-chemicals-and-carcinogens
  • ▲7.  O'Neil, M.J. et al., The Merck Index : an encyclopedia of chemicals, drugs, & biologicals. 15e éd. Cambridge, G.-B. : Royal Society of Chemistry. (2013). [RM-403001]   https://www.rsc.org/Merck-Index/
  • ▲8.  National Fire Protection Association, Fire protection guide to hazardous materials. 14th ed. Quincy, Mass. : NFPA. (2010). [RR-334001]
  • ▲9.  Lenga, R.E. et Votoupal, K.L., The Sigma-Aldrich library of regulatory and safety data. Vol. 1. Milwaukee : Sigma-Aldrich. (1993). [RM-515040]
  • ▲10.  Règlement sur la santé et la sécurité du travail [S-2.1, r. 13]. Québec : Éditeur officiel du Québec. [RJ-510071]   http://legisquebec.gouv.qc.ca/fr/ShowDoc/cr/S-2.1,%20r.%2013
  • ▲13.  Bingham, E., Cohrssen, B. et Powell, C.H., Patty's toxicology. A Wiley-Interscience publication. New York (Toronto) : John Wiley. (2001-). [RM-214008]   http://www3.interscience.wiley.com (http://www3.interscience.wiley.com/cgi-bin/mrwhome/104554795/HOME)
  • ▲14.  Deutsche Forschungsgemeinschaf, «Piperazine.» In: [MAK Value Documentation,1998]. The MAK Collection for Occupational Health and Safety. , p. 304-313. Wiley-VCH. (2012).   http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb11085kske0009/pdf
  • ▲15.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  • ▲16.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲17.  Carpenter, C.P. et Smyth, H.F., «Chemical burns of the rabbit cornea.» American Journal of Ophthalmology. Vol. 29, p. 1363-1372. (1946). [AP-021658]
  • ▲18.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 2, 4éme éd. Springfield, ILL : Charles C. Thomas. (1993). [RM-515030]
  • ▲19.  Bureau européen des substances chimiques, European Union Risk Assessment Report : Piperazine. 3nd Priority List, Vol. 56. Luxembourg : Office for Official Publications of the European Communities. (2005). EUR 21642.   https://echa.europa.eu/documents/10162/35f9602c-cb84-448f-9383-250e1a5ad350
  • ▲20.  Deutsche Forschungsgemeinschaf, «Piperazine.» In: [MAK Value Documentation,1999]. The MAK Collection for Occupational Health and Safety. , p. 178. Wiley-VCH. (2012).   http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb11085kske0012/pdf
  • ▲21.  Welinder, H., Hagmar, L. et Gustavsson, C., «IgE antibodies against piperazine and N-methyl-piperazine in two asthmatic subjects.» International Archives of Allergy and Applied Immunology. Vol. 79, no. 3, p. 259-262. (1986). [AP-061816]
  • ▲22.  Hagmar, L. et al., «Small airways function in workers exposed to piperazine.» International Archives of Occupational and Environmental Health. Vol. 59, p. 521-528. (1987).
  • ▲23.  Hagmar, L. et al., «Piperazine-induced occupational asthma.» Journal of Occupational Medicine. Vol. 24, no. 3, p. 193-197. (1982).
  • ▲24.  Hagmar, L. et al., «Piperazine-induced airway symptoms: exposure-response relationships and selection in an occupational setting.» American Journal of Industrial Medicine. Vol. 6, p. 347-357. (1984).
  • ▲25.  Hagmar, L. et Welinder, H., «Prevalence of specificIgE antibodies against piperazine in employees of a chemical plant.» International Archives of Allergy and Applied Immunology. Vol. 81, no. 1, p. 12-16. (1986).
  • ▲26.  Graham, C., Rosenkranz, H.S. et Karol, M.H., «Structure-activity model of chemicals that cause human respiratory sensitization.» Regulatory Toxicology and Pharmacology. Vol. 26, p. 296-306. (1997).
  • ▲27.  Fregert, S., «Respiratory symptoms with piperazine patch testing.» Contact Dermatitis. Vol. 2, p. 61-62. (1976). [AP-061826]
  • ▲28.  Rudzki, E., Rebandel, P. et Grzywa, Z., «Contact allergy in the pharmaceutical industry.» Contact Dermatitis. Vol. 21, p. 121-122. (1989).
  • ▲29.  Calnan, C.D., «Occupational piperazine dermatitis.» Contact Dermatitis. Vol. 1, p. 126. (1975). [AP-019319]
  • ▲30.  Asthmagen? : critical assessments of the evidence for agents implicated in occupational asthma. Health and Safety Executive. Sudbury, Suffolk, G.B. : HSE Books. (2001). [MO-020018]   http://www.hse.gov.uk/asthma/asthmagen.pdf
  • ▲31.  Quierce S., Pelta R. et Sastre J., «Occupational Asthma due to Piperazine Citrate.» Journal of Investigational Allergology and Clinical Immunology. Vol. 16, no. 2, p. 138-139. (2006).   http://www.jiaci.org/issues/vol16issue02/10.pdf
  • ▲32.  van Kampen V., Merget R. et Baur X., «Occupational Airway Sensitizers : an Overview on the Respective Literature.» American Journal of Industrial Medicine. Vol. 38, no. 2, p. 164-218. (2000). [AP-058318]
  • ▲33.  Leung H.W. et Auletta C.S., «Evaluation of skin sensitization and cross-reaction of nine alkyleneamines in the guinea pig maximization test.» Journal of toxicology. Cutaneous and ocular toxicology. Vol. 16, no. 3, p. 189-195. (1997). [AP-053750]
  • ▲34.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲35.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
    http://www.tc.gc.ca/tmd/menu.htm

Autres sources d'information

  • Lide, D.R. , CRC handbook of chemistry and physics. 73rd ed. Boca Raton, Fla : CRC Press. (1992).
  • Mark, H.F., Grayson, M. et Eckroth, D., Kirk-Othmer encyclopedia of chemical technology. 3rd ed. New York : Wiley. (1978-84). [RT-423004]
  • Lewis, R.J., Sax's dangerous properties of industrial materials. Vol. 1, 8ème éd. New York : Van Nostrand Reinhold. (1992).
  • National Fire Protection Association, Fire protection guide on hazardous materials. 10th ed. Quincy, Mass. : NFPA. (1991). [RR-334001]   http://www.nfpa.org/
  • Lenga, R.E. et Votoupal, K.L., The Sigma-Aldrich library of regulatory and safety data. Vol. 1. Milwaukee : Sigma-Aldrich. (1993). [RM-515040]
  • Patty, F.A., Patty's industrial hygiene and toxicology. Vol. 2, 3rd ed. New York : John Wiley & Son. (1978).
  • Budavari, S. et O'Neil, M., The Merck index : an encyclopedia of chemicals, drugs, and biologicals. 11th ed. Rahway ( N.J.) : Merck. (1989). [RM-403001]
  • MSDS. PIPERAZINE, AKZO CHEMICALS LTD., 1991

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