WHMIS (m-dinitrobenzene)

Workplace Hazardous Materials Information System

WHMIS 2015 classification - Note to reader

• Combustible dusts - See comments below1 2

• Acute toxicity - oral - Category 33 4 5 6 7

• Acute toxicity - dermal - Category 43

• Reproductive toxicity - Category 24 8 9 10 11 12 13
• Toxic to the reproductive function

• Specific target organ toxicity - single exposure - Category 14 5 11 12 14 15 16 17

• Specific target organ toxicity - repeated exposure - Category 15 12 13 14 16 18 19

Danger

Toxic if swallowed (H301)
Harmful in contact with skin (H312)
Suspected of damaging fertility or the unborn child (H361)
Causes damage to organs (H370)
Causes damage to organs through prolonged or repeated exposure (H372)

Ingredient disclosure

Comments2 20 21 : This product could belong to the hazard class "Combustible dust", based on various factors related to the combustibility and explosiveness of its dust, including composition, shape and size of the particles.

A thermally unstable substance liable to undergo a strongly exothermic decomposition. Laboratory testing performed on the substance as packaged is nescessary to determine the category (Type A to G) of this hazard class.

References

• ▲1.  Vincoli, J.W., Risk management for hazardous chemicals : A-F. Vol. 1. Boca Raton : Lewis Publishers. (1997). [RM-515112]
• ▲2.  Pohanish, R.P. et Greene, S.A., Wiley guide to chemical incompatibilities. 3ème éd. New Jersey : John Wiley & Sons Inc. (2009). [RR-015033]   www.wiley.com
• ▲3.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
• ▲4.  Linder R.E., Hess R.A. et Strader L.F., «Testicular Toxicity and Infertility in male Rats Treated with 1.3-Dinitrobenzene.» Journal of Toxicology and Environmental Health. Vol. 19, p. 477-489. (1986).
• ▲5.  «Toxicology Update.» Journal of Applied Toxicology. Vol. 9, no. 3, p. 199-202. (1989). [AP-034003]
• ▲6.  Cairelli, S.G., Ludwig, H.R. et Whalen, J.J., Documentation for immediately dangerous to life or health concentrations (IDLHS). Cincinnati (OH) : NIOSH. (1994). PB-94-195047. [RM-515102]   http://www.cdc.gov/niosh/idlh/intridl4.html
• ▲7.  FitzGerald G.B. et al., «Acute Toxicological Evaluation of 1,3-Dinitrobenzene.» Journal of the American College of Toxicology, Part B. Vol. 1, p. 168-169. (1992). [AP-000485]
• ▲8.  Linder, R.E. et al., «Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. I - sperm quality, quantity and fertility ability.» Journal of Andrology. Vol. 9, no. 5, p. 317-326. (1988). [AP-026391]
• ▲9.  Hess, R.A. et al., «Acute effects and long-term sequelae of 1,3-dinitrobenzene on male reproduction in the rat. II - Quantitative and qualitative histopathology of the testis.» Journal of Andrology. Vol. 9, no. 5, p. 327-342. (1988). [AP-026392]
• ▲10.  Linder R.E. et al., «Reproductive Toxicology of a Single Dose of 1,3-Dinitrobenzene in Two Ages of Young Adult Male Rats.» Fundamental and Applied Toxicology. Vol. 14, p. 284-298. (1990).
• ▲11.  Blackburn D.M. et al., «A Comparaison of the Effetcts of the Three Isomers of Dinitrobenzene on the Testis in the Rat..» Toxicology and Applied Pharmacology. Vol. 92, p. 54-64. (1988).
• ▲12.  Lauwerys, R. et al., Toxicologie industrielle et intoxications professionnelles. 5ème éd. Issy-les-Moulineaux Cedex : Elsevier Masson SAS. (2007). [RM-514015]
• ▲13.  Cody, T.E. et al., «1,3-dinitrobenzene : toxic effects in vivo and in vitro.» Journal of toxicology and environmental health. Vol. 7, no. 5, p. 829-847. (May 1981). [AP-000938]
• ▲14.  Okubo T. et Shigeta S, «Anemia Cases after Acute m-Dinitrobenzene Intoxication due to an Occupationnal Exposure.» Industrial Health. Vol. 20, p. 297-304. (1982).
• ▲15.  Philbert M.A. et al., «1.3-Dinitrobenzene-induced Encephalapathy in Rats.» Neuropathology and Applied Neurobiology. Vol. 13, p. 371-389. (1987). [AP-000484]
• ▲16.  Agency for Toxic Substances and Disease Registry, Toxicological profile for 1,3-Dinitrobenzene and 1,3,5-Trinitrobenzene. Atlanta, GA : ATSDR. (1995).   http://www.atsdr.cdc.gov/ToxProfiles/tp74.pdf
• ▲17.  1,3-dinitrobenzene and 1,3,5-trinitrobenzene . ATSDR fact sheets . Atlanta, Ga : ATSDR. (1996). [RE-005455 ]
• ▲18.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 1, 4th ed. Springfield (ILL.) : Charles C. Thomas. (1993). [RM-515030]
• ▲19.  Bingham, E. et Cohrssen, B., Patty's toxicology. A Wiley-Interscience publication, 6ème éd. New York (NY) : John Wiley & Sons. (2012). [RM-214008]
• ▲20.  National Institute for Occupational Safety and Health, NIOSH pocket guide to chemical hazards. 3 ed. Cincinnati, Ohio : NIOSH. (2007). [RM-514001]   https://www.cdc.gov/niosh/npg/default.html
• ▲21.  United States Coast Guard et Department of Transport, Chemical Hazards Response Information System (CHRIS). Washington, D. C. : United States Coast Guard. (1999).   http://www.suttercountyfire.org/YSHMRT/CHRIS%20MANUAL%20CIM_16465_12C.pdf

The [number] refers to the Information SST database of the CNESST Documentation Center.