The section entitled Complete data sheet is not available in English for this substance. Consult the French version.

Identification

Description


Formule moléculaire brute : C15H22N2O2

Principaux synonymes

Noms français :

  • 4,4'-DICYCLOHEXYL METHANE DIISOCYANATE
  • 4,4'-DIISOCYANATODICYCLOHEXYLMETHANE
  • BIS(4-ISOCYANATOCYCLOHEXYL)METHANE
  • BIS(CYCLOHEXYL-4 ISOCYANATE) DE METHYLENE
  • CYCLOHEXANE, 1,1'-METHYLENE BIS(4-ISOCYANATO-)
  • Diisocyanate-4,4' de dicyclohexylméthane
  • H12 MDI
  • ISOCYANIC ACID, METHYLENEDI-4,1-CYCLOHEXYLENE ESTER
  • METHYLENE BIS (4-CYCLOHEXYL ISOCYANATE)
  • Methylene bis (4-cyclohexylisocyanate)
  • Methylene bis(4-cyclohexylisocyanate)
  • Methylene bis-(4-cyclohexylisocyanate)

Noms anglais :

  • Dicyclohexylmethane 4,4'-diisocyanate
  • DICYCLOHEXYLMETHANE-4,4'-DIISOCYANATE
  • HMDI
  • HYDROGENATED MDI
  • Methylene bis (4-cyclohexylisocyanate)
  • Methylene bis(4-cyclohexylisocyanate)
  • SMDI
Utilisation et sources d'émission

Fabrication de produits organiques

Références

  • ▲1.  National Institute for Occupational Safety and Health, NIOSH pocket guide to chemical hazards. 3 ed. Cincinnati, Ohio : NIOSH. (2007). [RM-514001]   https://www.cdc.gov/niosh/docs/2005-149/pdfs/2005-149.pdf
  • ▲2.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/t-06.pdf
  • ▲3.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  • ▲3.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  • ▲4.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲4.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲5.  OECD, «SIDS Initial Assessment Report for SIAM 20. 4,4'-Methylenedicyclohexyl Diisocyanate.» In: OECD Screening Information Data Set (SIDS) . Paris : UNEP Publications. (2005).   http://www.alipa.org/uploads/Modules/Publications/OECD%20SIDS%20H12MDI.pdf
  • ▲5.  OECD, «SIDS Initial Assessment Report for SIAM 20. 4,4'-Methylenedicyclohexyl Diisocyanate.» In: OECD Screening Information Data Set (SIDS) . Paris : UNEP Publications. (2005).   http://www.alipa.org/uploads/Modules/Publications/OECD%20SIDS%20H12MDI.pdf
  • ▲6.  Bernstein, D. et al., Asthma in the workplace. 2nd ed. New York : Marcel Dekker. (1999 ).
  • ▲7.  Toxicological Investigation of 1,1'-Methylenebis(4-isocyanatocyclohexane) With Cover Letter Dated 072987. (1987). Microfiche : OTS0515454
  • ▲7.  Toxicological Investigation of 1,1'-Methylenebis(4-isocyanatocyclohexane) With Cover Letter Dated 072987. (1987). Microfiche : OTS0515454
  • ▲8.  American Conference of Governmental Industrial Hygienists, «Methylene BIS(4-Cyclohexylisocyanate).» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2001). Publication #0100Doc.   http://www.acgih.org
  • ▲9.  Hughes M.A. et al., «Does Diisocyanate Exposure Results in Neurotoxicity?.» Clinical Toxicology. Vol. 52, no. 4, p. 242-257. (2014).   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025582/pdf/CTX-52-242.pdf
  • ▲10.  Rudzki, E. et Grzywa, Z., «4,4'Disocyanato dicyclohexyl methane (Hylene W) : a strong contact sensitizer.» Contact dermatitis. Vol. 3, no. 6, p. 344-346. (1977). [AP-022928]
  • ▲11.  White, I.R., Stewart, J.R. et Rycroft, R.J.G., «Allergic contact dermatitis from an organic di-isocyanate.» Contact dermatitis. Vol. 9, no. 4, p. 300-303. (1983). [AP-123322]
  • ▲12.  Thompson, T. et Belsito, D.V., «Allergic contact dermatitis from a diisocyanate in wool processing .» Contact dermatitis. Vol. 37, p. 239. (1997). [AP-056455]
  • ▲13.  Hoffman, T.E., «Allergic contact dermatitis to new plastic resins.» Archives of Dermatology. Vol. 118, p. 962. (1982). [AP-006217]
  • ▲14.  King, C.M., «Contact sensitivity to Hylene W.» Contact Dermatitis. Vol. 6, no. 5, p. 353-354. (1980). [AP-006218]
  • ▲15.  International Archives of Occupational and Environmental Health, VOL. 48, NO 2, 1981, P. 179-184
  • ▲16.  Emmett, E.A., «Allergic contact dermatitis in polyurethane plastic moulders.» Journal of Occupational Medicine. Vol. 18, no. 12, p. 802-804. (1976). [AP-022935]
  • ▲17.  Karol M.H. et Magreni C., «Extensive Skin Sensitization with Minimal Antibody Production in Guinea Pigs as a Result of Exposure to Dicyclohexylmethane-4,4'-diisocyanate.» Toxicology and Applied Pharmacology. Vol. 65, p. 291-301. (1982). [AP-019756]
  • ▲18.  Stadler J. et Karol M.H., «Experimental delayed Hypersensitivity Following Inhalation of Dicyclohexylmethane-4,4'-diisocyanate: A Concentration-Response Relationship.» Toxicology and Applied Pharmacology. Vol. 74, p. 244-249. (1984). [AP-019757]
  • ▲19.  Stadler J.C. et Karol M.H., «Use of Dose-Response Data to Compare the Skin Sensitizing Abilities of Dicyclohexylmethane-4,4'-diisocyanate and Picryl Chloride in Two Animal Species.» Toxicology and Applied Pharmacology. Vol. 78, p. 445-450. (1985). [AP-019758]
  • ▲20.  Israeli R., Smirnov V. et Sculsky M., «Intoxication due to Dicyclohexyl-methane-4,4'-diisocyanate Exposition.» International Archives of Occupational and Environmental Health. Vol. 482, p. 179-184. (1981). [AP-052998]
  • ▲21.  Thorne, P.S. et al., «Contact sensitivity by diisocyanates : potencies and cross-reactivities.» Toxicology and Applied Pharmacology. Vol. 87, no. 1, p. 155-165. (1987). [AP-136314]
  • ▲22.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲23.  Règlement sur la santé et la sécurité du travail [S-2.1, r. 13]. Québec : Éditeur officiel du Québec. [RJ-510071]   http://legisquebec.gouv.qc.ca/fr/ShowDoc/cr/S-2.1,%20r.%2013
  • ▲24.  Pauluhn J., Desmodur W, Acute Inhalation Toxicity in the Rat According to OECD Guideline No. 403. (1995). 8EHQ-0499-14423.

Autres sources d'information

  • MOBAY CHEMICAL CORPORATION, DIISOCYANATE-4,4' DE DICYCLOHEXYLMETHANE, 17 OCTOBRE 1988 (MSDS INFORMATION HANDLING SERVICES 5833-454 B-12)
  • Emmett, E.A., «Allergic contact dermatitis in polyurethane plastic moulders.» Journal of Occupational Medicine. Vol. 18, no. 12, p. 802-804. (1976). [AP-022935]
  • Karol M.H. et Magreni C., «Extensive Skin Sensitization with Minimal Antibody Production in Guinea Pigs as a Result of Exposure to Dicyclohexylmethane-4,4'-diisocyanate.» Toxicology and Applied Pharmacology. Vol. 65, p. 291-301. (1982). [AP-019756]
  • Stadler J. et Karol M.H., «Experimental delayed Hypersensitivity Following Inhalation of Dicyclohexylmethane-4,4'-diisocyanate: A Concentration-Response Relationship.» Toxicology and Applied Pharmacology. Vol. 74, p. 244-249. (1984). [AP-019757]
  • Stadler J.C. et Karol M.H., «Use of Dose-Response Data to Compare the Skin Sensitizing Abilities of Dicyclohexylmethane-4,4'-diisocyanate and Picryl Chloride in Two Animal Species.» Toxicology and Applied Pharmacology. Vol. 78, p. 445-450. (1985). [AP-019758]

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