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L'information disponible sur cette substance est partielle. Pour de plus amples renseignements, veuillez communiquer avec le Répertoire toxicologique.

Identification

Description


Formule moléculaire brute : C2HBrClF3

Principaux synonymes

Noms français :

  • Bromo-2 chloro-2 trifluoro-1,1,1 éthane
  • Halothane
  • Trifluoro-1,1,1 bromo-2 chloro-2 éthane

Noms anglais :

  • 1,1,1-Trifluoro-2-bromo-2-chloroethane
  • 1,1,1-Trifluoro-2-chloro-2-bromoethane
  • 2,2,2-Trifluoro-1-chloro-1-bromoethane
  • 2-Bromo-2-chloro-1,1,1-trifluoroethane
  • Ethane, 2-bromo-2-chloro-1,1,1-trifluoro-
  • Halothane
Utilisation et sources d'émission

Agent anesthésiant

Références

  • ▲1.  Direction des opérations, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2005). T-06. [MO-220007]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/t-06.pdf
  • ▲2.  Bowman, R.E. et Smith, R.F., «Behavioral and neurochemical effects of prenatal halothane.» Environmental Health Perspectives. Vol. 21, p. 189-193. (1977). [AP-045499]
  • ▲3.  Rodier, P.M. et Koeter, H.B.M.W., «General activity from weaning to maturity in mice exposed to halothane or nitrous oxide.» Neurobehavioral Toxicology and Teratology. Vol. 8, no. 2, p. 195-199. (1986). [AP-051931]
  • ▲4.  Rodier, P.M. et al., «Cell proliferation in developing brain after brief exposure to nitrous oxide or halothane.» Anesthesiology. Vol. 64, no. 6, p. 680-687. (1986). [ap-0551933]
  • ▲5.  Saillenfait, A.M. et al., «Postnatal hepatic and renal consequences of in utero exposure to halothane or its oxidative metabolite trifluoroacetic acid in the rat.» Journal of Applied Toxicology. Vol. 17, no. 1, p. 1-8. (1997). [AP-053206]
  • ▲6.  Ghantous, H. et al., «Distribution of halothane and the metabolites trifluoroacetic acid and bromide in the conceptus after halothane inhalation by pregnancy mice.» Acta pharmalogica et toxicologica. Vol. 59, no. 5, p. 370-376. (1986). [AP-045497]
  • ▲7.  Koeter, H.B.W.M. et Rodier, P.M., «Behavioral effects in mice exposed to nitrous oxide or halothane : prenatal vs postnatal exposure.» Neurobehavioral Toxicology and Teratology. Vol. 8, p. 189-194. (1986). [AP-045492]
  • ▲8.  Patsalos, P.N., Rigor, B.M. et Wiggins, R.C., «A halothane-related effect on rat brain myelination : a comparison of chronic prenatal or postnatal exposure.» Journal of neurochemistry. Vol. 35, no. 2, p. 412-416. (1980). [AP-045496]
  • ▲9.  Levine, E.D. et al., «Long-term effects of developmental halothane exposure on radial arm maze performance in rats.» Behavioral Brain Research. Vol. 36, no. 1-2, p. 147-154. (1990).
  • ▲10.  Conseil d'évaluation des technologies de la santé du Québec (CÉTS), Les risques de l'exposition professionnelle aux gaz anesthésiques pour la femme enceinte et le foetus. (CÉTS 96-3 RF). Montréal : CÉTS. (1996).
  • ▲11.  Wharton, R.S. et al., «Fertility, reproduction and postnatal survival in mice chronically exposed to halothane.» Anesthesiology. Vol. 48, p. 167-174. (1978).
  • ▲12.  Pope, W.D.P. et Persaud, T.V.N., «Fertility and reproduction after male rat exposure to halothane.» Experimental Pathology. Vol. 22, p. 59-62. (1982).
  • ▲13.  Baeder, C. et Albrecht, M., «Embryotoxic/teratogenic potential of halothane.» International Archives of Occupational and Environmental Health. Vol. 62, p. 263-271. (1990).
  • ▲14.  Mazze, R.I., Fujinaga, M. et Baden, J.M., «Halothane prevents nitrous oxide teratogenicity in Sprague-Dawley rats; Folinic acid does not.» Teratology. Vol. 38, p. 121-127. (1988).
  • ▲15.  Mazze, R.I. et al., «Reproductive and teratogenic effects of nitrous oxide, halothane, isoflurane, and enflurane in Sprague-Dawley rats.» Anesthesiology. Vol. 64, p. 339-344. (1986).
  • ▲16.  Pope, W.D.B. et al., «Fetotoxicity in rats following chronic exposure to halothane, nitrous oxide, or methoxyflurane.» Anesthesiology. Vol. 48, p. 11-16. (1978).
  • ▲17.  Pope, W.D.B. et al., «Lack of teratogenic dangers with halothane.» Acta Anaesthesiologica Belgica. Vol. 26, p. 169-173. (1975).
  • ▲18.  Lansdown, A.B.G. et al., «Analysis of fetal development in rats following maternal exposure to subanesthetic concentrations of halothane.» Teratology. Vol. 13, p. 299-304. (1976).
  • ▲19.  Koeter, H.B.W.M. et Rodier, P.M., «Some immediate effects of anesthetics on brain development of mice.» Teratology. Vol. 32, no. 2, p. 26A. (1985).
  • ▲20.  Ott, M. G., Diller, W. F. et Jolly, A. T., «Respiratory effects of toluene diisocyanate in the workplace: a discussion of exposure-response relationships.» Critical Reviews in Toxicology. Vol. 33, no. 1, p. 1-59. (2003).
  • ▲21.  Cameron, A.M. et al., «Inhalation of enflurane and halothane at subanesthetic concentrations and effects on circulating serum testosterone, luteinizing hormone and follicle-stimulating hormone in the male rats..» Toxicology Letters. Vol. 19, p. 333-338. (1983).
  • ▲22.  Hale, T., Medications and mother's milk. 9th ed. Amarillo (Texas) : Pharmasoft Publishing. (2000). [RM-415009]
  • ▲23.  Shelley, M.L., Andersen, M.E. et Fischer, J.W., «A risk assessment approach for nursing infants exposed to volatile organics through the mother's occupational inhalation exposure.» Applied Industrial Hygiene. Vol. 4, no. 1, p. 21-26. (1989). [AP-024815]
  • ▲24.  Fisher, J. et al., «Lactational transfer of volatile chemicals in breast milk.» American Industrial Hygiene Association Journal. Vol. 58, no. 6, p. 425-431. (1997). [AP-051996]
  • ▲25.  Côté, C.J. et al., «Trace concentrations of halothane in human breast milk.» British Journal of Anaesthesia. Vol. 48, no. 6, p. 541-543. (1976). [AP-005716]
  • ▲26.  Preib, A. et al., «The determination of trifluoroacetic acid in rat milk samples by 19F-NMR spectroscopy and capillary gas chromatography.» Journal of Pharmaceutical and Biomedical Analysis. Vol. 16, p. 1381-1385. (1998). [AP-059474]
  • ▲27.  Schaude, G., «Cytological liver changes after chronic use of halothane and methoxyflurane in animal experiments.» Anaesthesiology and Resuscitation. Vol. 89, p. 117-132. (1975).
  • ▲28.  Eger, E.I. et al., «A test of the carcinogenicity of enflurane, isoflurane, halothane, methoxyflurane, and nitrous oxide in mice.» Anesthesia and Analgesia. Vol. 57, p. 678-694. (1978).
  • ▲29.  Baden, J.M. et al., «Carcinogenicity of halothane in Swiss/ICR mice.» Anesthesiology. Vol. 51, p. 20-26. (1979).
  • ▲30.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Overall evaluations of carcinogenicity : an updating of IARC monographs volumes 1-42. IARC monographs on the evaluation of carcinogenic risks to humans, Supplement 7. Lyon : International Agency for Research on Cancer. (1987). [MO-011531]   http://www.iarc.fr ou
    http://monographs.iarc.fr/
  • ▲31.  IARC Working Group on the Evaluation of Carcinogenic Risks of Chemical to Man, Cadmium, nickel, some epoxides, miscellaneous industrial chemicals and general considerations on volatile anaesthetics. IARC monographs on the evaluation of carcinogenic risks of chemical to man, Vol. 11. Lyon : International Agency for Research on Cancer. (1976). [MO-023436]   http://www.iarc.fr
  • ▲32.  American Conference of Governmental Industrial Hygienists, 2014 TLVs® and BEIs® : threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati (OH) : ACGIH. (2014). Publication 0114. [NO-003164]   http://www.acgih.org
  • ▲33.  Robbiano, L. et al., «Increased frequency of micronucleated kidney cells in rats exposed to halogenated anaesthetics.» Mutation Research. Vol. 413, p. 1-6. (1998).
  • ▲34.  Basler, A. et Rohrborn,G., «Lack of mutagenic effects of halothane in mammals In vivo.» Anesthesiology. Vol. 55, p. 143-147. (1981).
  • ▲35.  Galloway, S.M. et al., «Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals.» Environmental and Molecular Mutagenesis. Vol. 10, no. Suppl.10, p. 1-175. (1987). [AP-025242]
  • ▲36.  White, A.E. et al., «Sister chromatid exchanges induced by inhaled anesthetics.» Anesthesiology. Vol. 50, p. 426-430. (1979).
  • ▲37.  Sturrock.J., «Lack of mutagenic effect of halothane or chloroform on cultured cells using the azaguanine test system.» British Journal of Anaesthesia. Vol. 49, p. 207. (1977).
  • ▲38.  Kusyk, C. et Hsu, T.C., «Mitotic anomalies induced by three inhalation halogenated anesthetics.» Environmental Research. Vol. 12, p. 366-370. (1976).
  • ▲39.  Reitz, M. et Lanz, E., «DNA strand breaks in cells with DNA repair deficiency after halothane exposure in vitro.» Arzneimittel-Forschung = Drug Research. Vol. 43, no. 4, p. 418-420. (1993).
  • ▲40.  Règlement sur la santé et la sécurité du travail [S-2.1, r. 13]. Québec : Éditeur officiel du Québec. (2007). [RJ-510071]   http://www3.publicationsduquebec.gouv.qc.ca/loisreglements.fr.html
    http://www2.publicationsduquebec.gouv.qc.ca/dynamicSearch/telecharge.php?type=3&file=/S_2_1/S2_1R13.HTM (À jour au 1er décembre 2012)

Autres sources d'information

  • American Conference of Governmental Industrial Hygienists, 2010 TLVs and BEIs with 7th edition documentation CD-ROM. Cincinnati, OH : ACGIH. (2010). Publication 0111CD. [CD-120061]   http://www.acgih.org
  • Mark, H.F., Grayson, M. et Eckroth, D., Kirk-Othmer encyclopedia of chemical technology. 3rd ed. New York : Wiley. (1978-84). [RT-423004]
  • Lenga, R.E., The Sigma-Aldrich library of chemical safety data. 2nd ed. Milwaukee : Sigma-Aldrich. (1988).
  • Budavari, S. et O'Neil, M., The Merck index : an encyclopedia of chemicals, drugs, and biologicals. 11th ed. Rahway ( N.J.) : Merck. (1989). [RM-403001]
  • International Labour Office, Encyclopaedia of occupational health and safety : A-K. Vol. 1, 3rd ed. Geneva : ILO. (1983).
  • Hawley, G. G., Sax, N. I. et Lewis, R. J., Hawley's condensed chemical dictionary. 11th ed. rev. New York : Van Nostrand Reinhold. (1987). [RS-407001]
  • JOURNAL OF APPLIED TOXICOLOGY, VOL.3, NO. 6, 1983, P. 278
  • France. Institut national de recherche et de sécurité, Fiche toxicologique no 174 : Halothane. Cahiers de notes documentaires. Paris : INRS. (1988). [RE-005509]   http://www.inrs.fr/accueil/produits/bdd/recherche-fichetox-criteres.html
    http://www.inrs.fr/default/dms/inrs/FicheToxicologique/TI-FT-174/ft174.pdf
  • Hansch, C. et Leo, A., The log P database. Claremont, Ca. : Pomona College. (1987).

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