Formule moléculaire brute : C6H12N2S4

Principaux synonymes

Noms français :

  • Thiram
  • Thirame
  • Thiram®

Noms anglais :

  • Thiram
  • Thiram®
Utilisation et sources d'émission

Ce produit est utilisé dans plusieurs applications et dans différents secteurs d'activités, en voici quelques exemples :

• Agent de vulcanisation pour le caoutchouc.
• Fongicide.
• Insecticide.
• Additif pour huiles lubrifiantes.
• Répulsif pour animaux.


  • ▲1.  Cairelli, S.G., Ludwig, H.R. et Whalen, J.J., Documentation for immediately dangerous to life or health concentrations (IDLHS). Springfield (VA) : NTIS. (1994). PB-94-195047. [RM-515102]
  • ▲2.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]
  • ▲6.  Deutsche Forschungsgemeinschaft. Kommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe, Occupational toxicants : critical data evaluation for MAK values and classification of carcinogens. Weinheim; New York : VCH. (1991-). [MO-020680]
  • ▲7.  committee of the Health Council of the Netherlands, Thiram (CAS No: 137-26-8): . Health-based Reassessment of Administrative Occupational Exposure Limits, No. 2000/15OSH/090. The Hague,. (2003).
  • ▲8.  American Conference of Governmental Industrial Hygienists, «Thiram.» In: Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. Cincinnati, Ohio : ACGIH. (2014). Publication #0100Doc.
  • ▲9.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]
  • ▲10.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety
  • ▲11.  Lisi, P., Caraffini, S. et Assalve, D., «Irritation and sensitization potential of pesticides.» Contact Dermatitis. Vol. 17, p. 212-218. (1987).
  • ▲12.  Kiec-Swierczynska, M., «Occupational sensitivity to rubber.» Contact Dermatitis. Vol. 32, no. 3, p. 171-172. (1995). [AP-063908]
  • ▲13.  Ikarashi, Y., Tsuchiya, T. et Nakamura, A., «Evaluation of contact sensitivity of rubber chemicals using the murine local lymph node assay.» Contact Dermatitis. Vol. 28, p. 77-80. (1993).
  • ▲14.  Kilpikari, I., «Occupational contact dermatitis among rubber workers.» Contact Dermatitis. Vol. 8, p. 359-362. (1982).
  • ▲15.  Themido, R. et Menezes Brandao, F., «Contact allergy to thiurams.» Contact Dermatitis. Vol. 10, p. 251. (1984). [AP-026365]
  • ▲16.  van Och, F.M.M. et al., «Comparison of dose-responses of contact allergens using the guinea pig maximization test and the local lymph node assay.» Toxicology. Vol. 167, no. 3, p. 207-215. (2001).
  • ▲17.  van Och, F.M.M. et al., «A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay : employment of a regression method that includes determination of the uncertainty margins.» Toxicology. Vol. 146, no. 1, p. 49-59. (2000).
  • ▲18.  Klein, M.K., Brancaccio, R. et Cohen, D., «Occupational allergic contact dermatitis in an obstetrics and gynecology resident.» American Journal of Contact Dermatitis. Vol. 14, no. 4, p. 217-218. (2003).
  • ▲19.  van Ketel, W.G., «Contact urticaria from rubber gloves after dermatitis from thiurams.» Contact Dermatitis. Vol. 11, p. 323-324. (1984). [AP-053282]
  • ▲20.  Condé-Salazar, L. et al., «Occupational allergic contact dermatitis in construction workers.» Contact Dermatitis. Vol. 33, p. 226-230. (1995). [AP-063483]
  • ▲21.  Saunders, H. et Watkins, F., «Allergic contact dermatitis due to thiuram exposure from a fungicide.» Australasian Journal of Dermatology. Vol. 42, no. 3, p. 217-218. (2001).
  • ▲22.  Foussereau, J. et Cavelier, C., «La N-isopropyl-N'-phénylparaphénylènediamine a-t-elle sa place dans la batterie standard d'allergènes? Importance de cet allergène dans l'intolérance au caoutchouc.» Dermatologica. Vol. 155, p. 164-167. (1977).
  • ▲23.  Camarasa, J.M.G, «First epidemiological study of contact dermatitis in Spain - 1977.» Acta Dermato-Venereologica. Vol. 59, no. 85, p. 33-37. (1979). [AP-020884]
  • ▲24.  Baer, R.L., Ramsey, D.L. et Biondi, E., «The most common contact allergens.» Archives of Dermatology. Vol. 108, p. 74-78. (1973). [AP-022042]
  • ▲25.  Rudzki, E., Rebandel, P. et Grzywa, Z., «Contact allergy in the pharmaceutical industry.» Contact Dermatitis. Vol. 21, p. 121-122. (1989).
  • ▲26.  Matsushita, T. et al., «Experimental study on cross-contact allergy due to dithiocarbamate fungicides.» Industrial Health. Vol. 15, no. 1-2, p. 87-94. (1977).
  • ▲27.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Occupational exposures in insecticide application, and some pesticides. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 53. Lyon : International Agency for Research on Cancer. (1991).

  • ▲28.  American Conference of Governmental Industrial Hygienists, 2018 TLVs® and BEIs® : threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati (OH) : ACGIH. (2018). [NO-003164]
  • ▲29.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.
  • ▲30.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.
  • ▲31.  International Programme on Chemical Safety, Environmental Health Criteria 78: Dithiocarbamates pesticides, ethylenethiourea, and propylenethiourea: a general introduction. Genève : World Health Organization. (1988). [MO-012204]
  • ▲32.  WEISS, L.R. et ORZEL, R.A. , «SOME COMPARATIVE TOXICOLOGIC AND PHARMACOLOGIC EFFECTS OF DIMETHYL SULFOXIDE AS A PESTICIDE SOLVENT.» Toxicology and Applied Pharmacology. Vol. 11, p. 546-557. (1967). [AP-023675]
  • ▲33.  Greim, H., Essential MAK Value Documentations from the MAK-Collection for Occupational Health and Safety. Allemagne : Wiley-VCH Verlag GmbH & Co. KGaA. (2006). [MO-004572]
  • ▲34.  BGIA-Gestis, Information system on hazardous substances of the Berufsgenossenschaften. Sankt Augustin, Germany : Berufsgenossenschaftliches Institut.

Autres sources d'information

  • Schardein, J.L., Chemically induced birth defects. 3ème rév. & expanded. New York : Dekker. (2000). [MO-122294]
  • Hayes, W.J. et Laws, E.R., Handbook of pesticides toxicology : general principles. Vol. 1. Toronto : Academic Press. (1991).
  • Shepard, T.H., Catalog of teratogenic agents. 9th ed. Baltimore : The John Hopkins University Press. (1998). [RM-515003]
  • Danielsson, B. R. , Oskarsson, A. et Dencker, L. , «Placental transfer and fetal distribution of lead in mice after treatment with dithiocarbamates.» Archives of Toxicology. Vol. 55, no. 1, p. 27-33. (1984).
  • Stoker, T. E. et al., «Abnormal fertilization is responsible for reduced fecundity following thiram-induced ovulatory delay in the rat.» Biology of reproduction. Vol. 68, no. 6, p. 2142-2149. (2003).
  • Stoker, T. E. et al., «The fungicide thiram delays ovulation and alters fertility in the rat.» Toxicologist . Vol. 14, no. 1, p. 77. (1994).
  • Andreyev, M. V. et Kvartovkina, L. K. , «Impairment of reproductive health in women occupationally exposed to thiram.» Reproductive Toxicology. Vol. 7, no. 5, p. 491. (1993).
  • Aleksandrov, S. E. , «[Effect of vulcanizing accelerants on embryolethality in rats] .» Biulleten' eksperimental'noi biologii i meditsiny. Vol. 93, no. 1, p. 87-88. (1982).
  • You, X., «[Mutagenicity and teratogenicity study of thiram] .» Kung Yeh Wei Sheng Yu Chih Yeh Ping. Vol. 17, no. 4, p. 202-206. (1991).
  • Roll, R., «Teratological investigations with Thiram(TMTD) on two strains of mice.» Arch. Toxikol.. Vol. 27, p. 173-186. (1971).
  • Robens, J. F., «Teratologic studies of Carbaryl, Diazinon, Norea, Disulfiram and Thiram small laboratory animkals.» Toxicology and Applied Pharmacology. Vol. 15, p. 152-163. (1969).
  • Sal'nikova, L. S. , «[Study of the embryotropic effect of tiuram EF].» Gigiena i sanitariia. Vol. 3, p. 88. (1989).
  • Environmental Protection Agency, Reregistration Eligibility Decision for Thiram. Washington. (2004).
  • Stoker, T. E. et al., «Characterization of pregnancy outcome following thiram-induced ovulatory delay in the female rat.» Neurotoxicology and teratology . Vol. 18, no. 3, p. 277-282. (1996).
  • Dãnulescu, E. et al., «Reproductive effects of the fungicide Thiram. Epidemiological and experimental studies.» The Journal of Preventive Medicine. Vol. 12, no. 1-2, p. 38-45. (2004).
  • Joint WHO/FAO Meeting on Pesticide Residues, Pesticide residues in food - 1996. Part 1 - Residues. Pesticide residues in food. Genève : World Health Organization : International Programme of Chemical Safety. (1996).
  • Roll, R., «[Teratologic studies with Thiram (TMTD) on two strains of mice] .» Archiv fur Toxikologie. Vol. 27, no. 3, p. 173-186. (1971).
  • Vasilos, A. F. et al., «The reproductive function of rats in acute and chronic intoxication with tetra methyl thiuram di sulfide .» Gig Sanit. Vol. 6, p. 37-40. (1978).
  • Short, R. D. Jr et al., «Developmental toxicity of ferric dimethyldithiocarbamate and bis(dimethylthiocarbamoyl) disulfide in rats and mice.» Toxicology and applied pharmacology. Vol. 35, no. 1, p. 83-94. (1976).
  • Zhavororkov, N. I. , «Assessment of the effect of pesticides on reproductive function of animals..» Veterinariya (Moscow). Vol. 9, p. 67-69. (1979).

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