KOPROL - Synonyme de

Numéro CAS : 77-09-8

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  • Résumé

Identification

Description


Formule moléculaire brute : C20H14O4

Principaux synonymes

Noms français :

  • 1(3H)-ISOBENZOFURANONE, 3,3-BIS(4-HYDROXYPHENYL)-
  • 2,2-BIS(P-HYDROXYPHENYL)PHTHALIDE
  • 3,3-BIS(4-HYDROXYPHENYL)-1-(3H)-ISOBENZOFURANONE
  • 3,3-BIS(P-HYDROXYPHENYL)PHTHALIDE
  • ALPHA-(P-HYDROXYPHENYL)-ALPHA-(4-OXO-2,5-CYCLOHEXADIEN-1-YLID-INE)-O-TOLUIC ACID
  • ALPHA-(P-HYDROXYPHENYL)-ALPHA-(4-OXO-2,5-CYCLOHEXADIEN-1-YLIDINE)-O-TOLUIC ACID
  • PHENOLPHTALEINE
  • PHENOLPHTALEINE, INDICATEUR
  • Phénolphtaléine

Noms anglais :

  • Phenolphthalein
  • Phenolphthaleine

Références

  • ▲1.  Griffin, R.J., Godfrey, V.B. et Burka, L.T., «Metabolism and disposition of phenolphthalein in male and female F344 rats and B6C3F1 mice.» Toxicological Sciences. Vol. 42, p. 73-81. (1998).
  • ▲2.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Some antiviral and antineoplastic drugs, and other pharmaceutical agents. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 76. Lyon : International Agency for Research on Cancer. (2000).   https://monographs.iarc.fr/wp-content/uploads/2018/06/mono76.pdf
    http://www.iarc.fr
  • ▲3.  Visek, B.D., Liu, W.C. et Roth, L.J., «Studies on the fate of carbon-14 labeled phenolphthalein.» Journal of Pharmacology and Experimental Therapeutics. Vol. 117, p. 347-357. (1956).
  • ▲4.  Collins, B.J., Grizzle, T.B. et Dunnick, J.K., «Toxicokinetics of phenolphthalein in male and female rats and mice.» Toxicological Sciences. Vol. 56, no. 2, p. 271-281. (2000).
  • ▲5.  Toxicology and carcinogenesis studies of phenolphthalein (cas no. 77-09-8) in F344 rats and B6C3F1 mice (feed studies).. Research Triangle Park, NC : National Toxicology Program. (1996). NTP TR-465. Microfiche : PB97-169882
  • ▲6.  Report on Carcinogens, 15th edition. Research Triangle Park, NC : U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program. (2021).   https://ntp.niehs.nih.gov/pubhealth/roc/index-1.html
  • ▲7.  Heinonen, O. P., Shapiro, S. et Slone, D., Birth defect and drugs in pregnancy, Littleton, Massachusetts : Publishing Sciences Group, 1977 [MO-000066]
  • ▲8.  Gulati, D.K., Mounce, R.C., Russell, S., Final report on the reproductive toxicity of phenolphthalein (cas no. 77-09-8) In cd-1-swiss mice (revised)., 1991 Microfiche : PB91-178707, NTP-T0196
  • ▲9.  Wilson, J.T., Drugs in breast milk. Lancaster, England : MTP Press : International Medical Publishers. (1981). [MO-010024]
  • ▲10.  Briggs, G.G., Freeman, R.K. et Yaffe, S.J., Drugs in pregnancy and lactation : a reference guide to fetal and neonatal risk. 5ème éd. Baltimore : Williams & Wilkins. (1998).
  • ▲11.  Cooper, G.S. et al., «Risk of ovarian cancer in relation to use oe phenolphthalein-containing laxatives.» British Journal of Cancer. Vol. 83, no. 3, p. 404-406. (2000).
  • ▲12.  Food and Drug Administration, «Laxative drug products for Over-the-Counter human use.» Federal Register. Vol. 64, no. 19, p. 4535-4540. (1999).
  • ▲13.  Ravdin, P.M., Van Beurden, M. et Jordan, V.C., «Estrogenic effects of phenolphtalein on human breast cancer cells in vitro.» Breasr Cancer Reasearcg treatment. Vol. 9, p. 151-154. (1987).
  • ▲14.  Nieto, A., Garcia, C. et Lopez de Haro, M.S., «In vivo estrogenic and antiestrogenic activity of phenolphthalein and derivative.» Biochemistry International. Vol. 21, no. 2, p. 305-311. (1990).
  • ▲15.  Kerckaert, G.A. et al., «Use of the Syrian hamster embryo cell transformation assay for carcinogenicity prediction of chemicals currently being tested by the National Toxicology Program in rodent bioassays.» Environmental Health Perspectives. Vol. 104, suppl. 5, p. 1075-1084. (1996).
  • ▲16.  Tsutsui, T. et al., «Cell-transforming activity and genotoxicity of phenolphthalein in cultured Syrian hamster embryo cells.» International Journal of Cancer. Vol. 73, p. 697-701. (1997). [AP-058771]
  • ▲17.  Tice, R.R. et al., «Measurement of micronucleated erythrocytes and DNA damage during chronic ingestion of phenolphthalein in transgenic female mice heterozygous for the p53 gene.» Environmental and Molecular Mutagenesis. Vol. 31, p. 113-124. (1998).
  • ▲18.  Bishop, M.E. et al., «Phenolphthalein induces micronuclei in transgenic human lymphoblastoid cells.» Environmental and Molecular Mutagenesis. Vol. 32, p. 286-288. (1998).
  • ▲19.  Gibson, D.P. et al., «Induction of micronuclei in Syrian hamster embryo cells : comparison to results in the SHE cell transformation assay for National Toxicology Program test chemicals .» Mutation Research. Vol. 392, no. 1/2, p. 61-70. (1997).
  • ▲20.  Witt, K.L. et al., «Phenolphthalein : induction of micronucleated erythrocytes in mice.» Mutation Research. Vol. 341, no. 3, p. 151-160. (1995).
  • ▲21.  Biondi, O. et al., «Phenolphthalein induces chromosome aberrations in human and chinese hamster liver cells (CHEL) cultured in vitro.» Teratogenesis, Carcinogenesis, and Mutagenesis. Vol. 20, no. 4, p. 209-217. (2000).
  • ▲22.  Duerksen-Hughens, P.J., Yang, J. et Ozcan, O., «p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing.» Environmental Health Perspectives. Vol. 107, no. 10, p. 805-812. (1999).
  • ▲23.  Dietz, D.D. et al., «Subchronic (13-week) toxicity studies of oral phenolphthalein in Fischer 344 rats and B6C3F1 mice.» Fundamental and Applied Toxicology. Vol. 18, p. 48-58. (1992).

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