Méthyl isobutyl cétone

Numéro CAS : 108-10-1

Identification

Description


Numéro UN : UN1245

Formule moléculaire brute : C6H12O

Principaux synonymes

Noms français :

  • 2-Pentanone, 4-methyl-
  • 4-Methyl 2-pentanone
  • 4-Methyl-2-pentanone
  • 4-Methylpentan-2-one
  • Cétone, méthyl isobutyl-
  • Hexone
  • Isopropyl acétone
  • Isopropylacétone
  • Methylisobutylketone
  • Méthyl isobutyl cétone
  • Méthyl isobutylcétone
  • Méthyl-2 Pentanone-4
  • Méthyl-isobutyl-cétone
  • Méthylisobutyl cétone

Noms anglais :

  • 2-Methyl-4-pentanone
  • 2-Methylpropyl methyl ketone
  • 4-Methyl-2-oxopentane
  • Isobutyl methyl ketone
  • Ketone, isobutyl methyl
  • Methyl isobutyl ketone
  • Methyl isobutylketone
  • MIBK
  • MIK
Famille chimique
  • Cétone
Utilisation et sources d'émission 1

En industrie, la méthyl isobutyl cétone est utilisée comme :

  • solvant de laques (cellulosiques, polyuréthane)
  • solvant de peintures, vernis, détachants, agents de nettoyage, adhésifs, pesticides, etc.
  • solvant d'extraction de produits pharmaceutiques, gommes, résines, nitrocellulose
  • matière première pour la production de l'alcool méthylamylique
  • agent dénaturant de l'alcool éthylique
  • agent de saveur dans l'alimentation.

Elle est aussi présente naturellement dans plusieurs aliments (fruits, fromages, lait, café, bières, etc.).

Références

  • ▲2.  O’Neil, M.J., Smith, A. et Heckelman, P.E., The Merck index : an encyclopedia of chemicals, drugs, and biologicals. 13th ed. Cambridge, MA : Cambridge Soft; Merck & CO. (2001). [RM-403001]
  • ▲3.  Cairelli, S.G., Ludwig, H.R. et Whalen, J.J., Documentation for immediately dangerous to life or health concentrations (IDLHS). Springfield (VA) : NTIS. (1994). PB-94-195047. [RM-515102]   http://www.cdc.gov/niosh/idlh/intridl4.html
  • ▲4.  Kirk-Othmer encyclopedia of chemical technology. 4th ed. New York : John Wiley & Sons. (1991-1998). [RT-423004]
  • ▲6.  American Industrial Hygiene Association, Odor thresholds for chemicals with established occupational health standards. Akron, OH : AIHA. (1989). [RM-515061]
  • ▲7.  Handbook of organic industrial solvents. 6ème. Chicago : Alliance of American Insurers. (1987). [RT-435005]
  • ▲8.  Pohanish, R.P. et Greene, S.A., Wiley guide to chemical incompatibilities. 2nd ed. New York, N.Y. : Wiley Interscience. (2003). [RR-015033]
  • ▲10.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/t-06.pdf
  • ▲11.  Deutsche Forschungsgemeinschaft, List of MAK and BAT Values 2002 : maximum concentrations and biological tolerance values at the workplace. Report no. 38. Weinheim : Wiley-VCH. (2002). [RM-515093]
  • ▲12.  American Conference of Governmental Industrial Hygienists, Documentation of the biological exposure indices. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲13.  Truchon, G., Guide de surveillance biologique : prélèvement et interprétation des résultats. Études et recherches / IRSST, 6ème éd. Montréal : IRSST. (2004). T-03. [MO-008481]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/T-03.pdf
  • ▲24.  American Conference of Governmental Industrial Hygienists, 2010 TLVs and BEIs with 7th edition documentation CD-ROM. Cincinnati, OH : ACGIH. (2010). Publication 0111CD. [CD-120061]   http://www.acgih.org
  • ▲25.  Dutch Expert Committee for Occupational Standards, Health-based recommended occupational exposure limits for methyl isobutyl ketone. Den Haag (Netherlands) : Ministry of Social Affairs and Employment, Labour Inspectorate. (1991). RA 4/91.
  • ▲26.  Deutsche Forschungsgemeinschaft. Kommission zur Prüfung Gesundheitsschädlicher Arbeitsstoffe, Occupational toxicants : critical data evaluation for MAK values and classification of carcinogens. Weinheim; New York : VCH. (1991-). [MO-020680]   www.wiley-vch.de
    www.mak-collection.com
    http://onlinelibrary.wiley.com/book/10.1002/3527600418/topics
  • ▲27.  Duguay, A.B. et Plaa, G.L., «Tissue concentrations of methyl isobutyl ketone, methyl n-butyl ketone and their metabolites after oral or inhalation exposure.» Toxicology Letters. Vol. 75, p. 51-58. (1995).
  • ▲28.  Granvil, C.P., Sharkawi, M. et Plaa, G.L., «Metabolic fate of methyl n-butyl ketone, methyl isobutyl ketone and their metabolites in mice.» Toxicology Letters. Vol. 70, p. 263-267. (1994).
  • ▲29.  Hjelm, E.W. et al., «Percutaneous uptake and kinetics of methyl isobutyl ketone (MIBK) in the guinea-pig.» Toxicology Letters. Vol. 56, p. 79-86. (1991).
  • ▲30.  Hjelm, E.W. et al., «Exposure to methyl isobutyl ketone : toxicokinetics and occurrence of irritative and CNS symptoms in man.» International Archives of Occupational and Environmental Health. Vol. 62, p. 19-26. (1990).
  • ▲31.  DiVincenzo, G.D., Kaplan, C.J. et Dedinas, J., «Characterization of the metabolites of methyl n-butyl ketone, methyl iso-butyl ketone, and methyl ethyl ketone in guinea pig serum and their clearance.» Toxicology and Applied Pharmacology. Vol. 36, p. 511-522. (1976). [AP-060775]
  • ▲32.  Cosmetic Ingredient Review Expert Panel, «Safety assessment of MIBK (methyl isobutyl ketone).» International Journal of Toxicology. Vol. 23, no. suppl. 1, p. 29-57. (2004).
  • ▲33.  Sato, A. et Nakajima, T., «Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil.» British Journal of Industrial Medicine. Vol. 36, p. 231-234. (1979).
  • ▲34.  Bingham, E., Cohrssen, B. et Powell, C.H., Patty's toxicology. A Wiley-Interscience publication, 5ème éd. New York (NY) : John Wiley & Sons. (2001). [RM-214008]
  • ▲35.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 1, 4th ed. Springfield (ILL.) : Charles C. Thomas. (1993). [RM-515030]
  • ▲36.  Bates, N., «Methyl Isobutyl Ketone (MIBK).» In: Toxicology of solvents. , p. 263-270. G-B : RAPRA Technology. (2002). [MO-024601]
  • ▲37.  Methyl Isobutyl Ketone. Joint Assessment of Commodity Chemicals, no. 8. Bruxelles : European Centre for Ecotoxicology and Toxicology of Chemicals. (1987). [MO-360075]   http://www.ecetoc.org
  • ▲38.  Gagnon, P., Mergler, D. et Lapare, S., «Olfactory adaptation, threshold shift and recovery at low levels of exposure to methyl isobutyl ketone (MIBK).» Neurotoxicology. Vol. 15, no. 3, p. 637-642. (1994). [AP-046664]
  • ▲39.  U.S. Environmental Protection Agency, Toxicological review of Methyl isobutyl ketone (Cas No. 108-10-1) in support of summary information on the integrated risk information system (IRIS). Washington, DC. (2003). EPA/635/R-03/002.   http://www.epa.gov/ncea/iris/toxreviews/0173tr.pdf
  • ▲40.  Grober, E. et Schaumburg, H.H., «Occupational exposure to methyl isobutyl ketone causes lasting impairment in working memory.» Neurology. Vol. 54, no. 9, p. 1853-1855. (2000).
  • ▲41.  Hansen, L.E., Methyl isobutyl ketone. Denmark : Danish Technological Institute. (1991). [AP-051940]
  • ▲42.  Dowty, B.J., Laseter, J.L. et Storer, J., «The transplacental migration and accumulation in blood of volatile organic constituents.» Pediatric Research. Vol. 10, p. 696-701. (1976). [AP-004611]
  • ▲43.  Tyl, R.W. et al., «Developmental toxicity evaluation of inhaled methyl isobutyl ketone in Fisher 344 rats and CD-1 mice.» Fundamental and Applied Toxicology. Vol. 8, p. 310-327. (1987). [AP-051604]
  • ▲44.  Lamm, S.H., Kutcher, J.S. et Morris, C.B., «Spontaneous abortions and glycol ethers used in the semiconductor industry: an epidemiologic review.» Occupational Hygiene. Vol. 2, no. 1-6, p. 339-354. (1996).
  • ▲45.  Union Carbide Corporation, Ninety-day inhalation study in rats and mice sponsored by CMA. Washington, DC : Chemical Manufacturers Association. (1983). Microfiche : OTS0507467, EPA/OTS; Doc #40-8344069
  • ▲46.  Nemec, M.D. et al., «Inhalation 2-generation reproductive toxicity study of methyl isobutyl ketone in rats.» Toxicologist. Vol. 60, no. 1, p. 250. (2001). [AP-063952]
  • ▲47.  Nemec, M.D. et al., «Inhalation two-generation reproductive toxicity study of methyl isobutyl ketone in rats.» International Journal of Toxicology. Vol. 23, no. 2, p. 127-143. (2004).
  • ▲48.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲49.  O'Donoghue, J.L. et al., «Mutagenicity studies on ketone solvents : methyl ethyl ketone, methyl isobutyl ketone, and isophorone.» Mutation Research. Vol. 206, p. 149-161. (1988). [AP-023843]
  • ▲50.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, A Review of Human Carcinogens: Some chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination by-products. IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 101. Lyon : International Agency for Research on Cancer. (2012).   http://monographs.iarc.fr/
    http://monographs.iarc.fr/ENG/Monographs/vol101/index.php
  • ▲51.  American Conference of Governmental Industrial Hygienists, 2017 TLVs® and BEIs® : threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati (OH) : ACGIH. (2017). Publication 0114. [NO-003164]   http://www.acgih.org
  • ▲52.  Brooks, T.M., Hutson, D.H. et Meyer, A.L., «The genetic toxicology of some hydrocarbon and oxygenated solvents.» Mutagenesis. Vol. 3, no. 3, p. 227-232. (1988). [AP-045389]
  • ▲53.  Löf, A. et Johanson, G., «Toxicokinetics of organic solvents : A review of modifying factors.» Critical Reviews in Toxicology. Vol. 28, no. 6, p. 571-650. (1998).
  • ▲54.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲55.  Smyth, H.F. Jr., Carpenter, C.P. et Weil, C.S., «Range-finding toxicity data : list IV.» Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, p. 119-122. (1951). [AP-060583]
  • ▲56.  Allan, R.E. et al., Patty's industrial hygiene and toxicology : toxicology. Vol. 2, part A, 4th ed. New York; Toronto : Wiley. (1993-1994). [RM-214008]
  • ▲57.  Grosse, Y. et al., «Carcinogenicity of chemicals in industrial and consumer products, food contaminants and flavourings, and water chlorination byproducts.» The Lancet Oncology. Vol. 12, no. 4, p. 328-329. (2011). [AP-000013]
  • ▲58.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
    http://www.tc.gc.ca/tmd/menu.htm

La cote entre [ ] provient de la banque ISST du Centre de documentation de la CSST.