Azote, protoxyde d'

Numéro CAS : 10024-97-2

L'information disponible sur cette substance est partielle. Pour de plus amples renseignements, veuillez communiquer avec le Répertoire toxicologique.

Identification

Description


Numéro UN : UN1070

Formule moléculaire brute : N2O

Principaux synonymes

Noms français :

  • Azote, protoxyde d'
  • Gaz hilarant
  • Hémioxyde d'azote
  • Oxyde azoteux
  • Oxyde nitreux
  • Protoxyde d'azote

Noms anglais :

  • Dinitrogen monoxide
  • Hyponitrous acid anhydride
  • Laughing gas
  • Nitrogen hypoxide
  • Nitrogen protoxide
  • Nitrous oxide
Utilisation et sources d'émission

Fabrication de propergol, agent anesthésiant

Références

  • ▲1.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/t-06.pdf
  • ▲3.  Trudell, J.R., «Metabolism of nitrous oxide.» Edward Arnold Publishers. Vol. 12, p. 203-210. (1980).
  • ▲4.  Giroud, J.-P., Mathé, G. et Meyniel, G., Pharmacologie clinique : bases de la thérapeutique. 2e éd. Paris : Expansion Scientifique Française. (1988). [RM-414008]
  • ▲5.  Damia, G. et Torri, G., «Caractéristiques physico-chimiques, cinétique d'absorption et d'élimination, technique d'emploi de l'enflurane.» Ann. Anesth. Franç. Vol. XVI, p. 573-586. (1975).
  • ▲6.  Koren, G. et Sloan, I., «The pharmacokinetics of inhaled N2O in children.» Research Communications in Chemical Pathology and Pharmacology. Vol. 49, no. 1, p. 95-108. (1985).
  • ▲7.  Pezzagno, G. et al., Biological indicators for the assessment of human exposure to industrial chemicals.
  • ▲8.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲9.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲10.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 267 : Protoxyde d'azote. Cahiers de notes documentaires. Paris : INRS. (2007).   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_267
  • ▲11.  Lauwerys, R. et al., Toxicologie industrielle et intoxications professionnelles. 5ème éd. Issy-les-Moulineaux Cedex : Elsevier Masson SAS. (2007). [RM-514015]
  • ▲12.  Hemminki, K, Kyyronen, P. et Lindbohm, M.L, «Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs and other potential hazards in hospitals, based on registered information outcome.» Journal of Epidemiology and Community Health. Vol. 39, p. 141-147. (1985). [AP-010898 ]
  • ▲13.  Hay, M.D., «Nitrous oxide transfer across the placenta and condition of the newborn at delivery.» British Journal of Obstetrics and Gynaecology. Vol. 85, p. 299-302. (1978).
  • ▲14.  Rodier, P.M. et Koeter, H.B.M.W., «General activity from weaning to maturity in mice exposed to halothane or nitrous oxide.» Neurobehavioral Toxicology and Teratology. Vol. 8, no. 2, p. 195-199. (1986). [AP-051931]
  • ▲15.  Rodier, P.M. et al., «Cell proliferation in developing brain after brief exposure to nitrous oxide or halothane.» Anesthesiology. Vol. 64, no. 6, p. 680-687. (1986). [ap-0551933]
  • ▲16.  Koeter, H.B.W.M. et Rodier, P.M., «Behavioral effects in mice exposed to nitrous oxide or halothane : prenatal vs postnatal exposure.» Neurobehavioral Toxicology and Teratology. Vol. 8, p. 189-194. (1986). [AP-045492]
  • ▲17.  Mazze, R.I., Fujinaga, M. et Baden, J.M., «Halothane prevents nitrous oxide teratogenicity in Sprague-Dawley rats; Folinic acid does not.» Teratology. Vol. 38, p. 121-127. (1988).
  • ▲18.  Mazze, R.I. et al., «Reproductive and teratogenic effects of nitrous oxide, halothane, isoflurane, and enflurane in Sprague-Dawley rats.» Anesthesiology. Vol. 64, p. 339-344. (1986).
  • ▲19.  Pope, W.D.B. et al., «Fetotoxicity in rats following chronic exposure to halothane, nitrous oxide, or methoxyflurane.» Anesthesiology. Vol. 48, p. 11-16. (1978).
  • ▲20.  Fujinaga, M. et al., «Reproductive and teratogenic effects of nitrous oxide, isoflurane, and their combination in Sprague-Dawley rats.» Anesthesiology. Vol. 67, p. 960-964. (1987).
  • ▲21.  Marx, G.F., Joshi, C.W. et Orkin, L.R., «Placental transmission of nitrous oxide.» Anesthesiology. Vol. 32, p. 429-432. (1970).
  • ▲22.  Stenger, V.G., Blechner, J.N. et Prystowsky, H., «A study of prolongation of obstetric anesthesia.» American Journal of Obstetrics and Gynecology. Vol. 103, p. 901. (1969).
  • ▲23.  Cohen, E.N. et al., «Occupational disease in dentristy and chronic exposure to trace anesthetic gases.» Journal of the American Dental Association. Vol. 101, p. 21-31. (1980).
  • ▲24.  Axelsson, G., Ahlborg, G. et Bodin, L., «Shift work, nitrous oxide exposure, and spontaneous abortion among Swedish midwives.» Occupational and Environmental Medicine. Vol. 53, p. 374-378. (1996).
  • ▲25.  Rowland, A.S. et al., «Reduced fertility among women employed as dental assistants exposed to high levels of nitrous oxide.» New England Journal of Medicine. Vol. 327, p. 993-997. (1992). [AP-040420]
  • ▲26.  Aldridge, L.M. et Tunstall, M.E., «Nitrous oxide and the fetus.» British Journal of Anesthesiology. Vol. 58, p. 1348-1356 . (1986). [AP-052363]
  • ▲27.  Ericson, H.A. et Kallen, A.J.B., «Hospitalisation for miscarriage and delivey outcome among Swedish nurses working in operating room personnel : a national study.» Anesthesia and Analgesia. Vol. 64, p. 981-988. (1985).
  • ▲28.  Mazze, R.I. et al., «Reproduction and fetal development in mice chronically exposed to nitrous oxide.» Teratology. Vol. 26, p. 11-16. (1982). [AP-005373]
  • ▲29.  Mazze, R.I. et al., «Reproduction and fetal development in rats exposed to nitrous oxide.» Teratology. Vol. 30, p. 259-264. (1984). [AP-051189]
  • ▲30.  Shah, R.M., Burdett, D.N. et Donaldson, D., «The effects of nitrous oxide on the developing hamster embryos.» Canadian Journal of Physiology and Pharmacology. Vol. 57, p. 1229-1232. (1979). [AP-005344]
  • ▲31.  Corbett, T.H. et al., «Effects of low concentrations of nitrous oxide on rat pregnancy.» Anesthesiology. Vol. 39, p. 299-301. (1973).
  • ▲32.  Vieira, E., «Effect of the chronic administration of nitrous oxide 0.5 % to gravid rats.» British Journal of Anaesthesia. Vol. 51, p. 283-287. (1979).
  • ▲33.  Vieira, E. et al., «Effects of low concentrations of nitrous oxide on rat fetuses.» Anesthesia and Analgesia. Vol. 59, p. 175-177. (1980). [AP-050856]
  • ▲34.  Vieira, E., Cleaton-Jones, P. et Moyes, D., «Effects of low intermittent concentrations of nitrous oxide on the developing rat fetus.» British Journal of Anaesthesia. Vol. 55, p. 67-69. (1983).
  • ▲35.  Tassinari, M.S., Mullenix, P.J. et Moore, P.A., «The efefcts of nitrous oxide after exposure during middle and late gestation.» Toxicology and Industrial Health. Vol. 2, p. 261-271. (1986). [AP-051188]
  • ▲36.  Fujinaga, M., Baden, J.M. et Mazze. R.I., «Susceptible period of nitrous oxide teratogenicity in Sprague-Dawley rats.» Teratology. Vol. 40, p. 439-444. (1989). [AP-027722]
  • ▲37.  Fujinaga, M. et al., «Nitrous oxide alters body laterality in rats.» Teratology. Vol. 41, p. 131-135. (1990). [AP-051163]
  • ▲38.  Fujinaga, M. et al., «Rat whole embryo culture : An in vitro model for testing nitrous oxide teratogenicity.» Anesthesiology. Vol. 69, p. 401-404. (1988). [AP-051619]
  • ▲39.  Fink, B.R., Shepard, T.H. et Blandau, R.J., «Teratogenic activity of nitrous oxide.» Nature. Vol. 214, p. 146-148. (1967). [AP-005343]
  • ▲40.  Lane, G.A. et al., «Anesthetics as teratogens : nitrous oxide is fetotoxic, xenon is not.» Science. Vol. 210, p. 899-890. (1980). [AP-051945]
  • ▲41.  Lane, G.A. et al., «Nitrous oxide is teratogenic : halothane is not.» Anesthesiology. Vol. 55, no. 3, p. A252. (1981).
  • ▲42.  Baden, J.M. et Fujinaga ,M., «Effects of nitrous oxide on day 9 rat embryos grown in culture.» British Journal of Anaesthesia. Vol. 66, p. 500-503. (1991). [AP-051903]
  • ▲43.  Fujinaga, M. et Baden, J.M., «Mechanisms of nitrous oxide-induced reproductive toxicity in rat embryos grown in culture.» Teratology. Vol. 45, no. 5, p. 476. (1992). [AP-051620]
  • ▲44.  Holson, R.R. et al., «Behavioral teratology and dominant lethal evaluation of nitrous oxide exposure in rats.» Neurotoxicology and Teratology. Vol. 17, no. 5, p. 583-592. (1995). [AP-048896]
  • ▲45.  Rice, S.A. et Milan, D.P., «Behavioral effects of in utero nitrous oxide exposure in adult SW mice.» Teratology. Vol. 31, no. 3, p. 6B. (1985). [AP-051196]
  • ▲46.  Rice, S.A., «Effect of prenatal N2O exposure on startle reflex reactivity.» Teratology. Vol. 42, p. 373-381. (1990). [AP-032660]
  • ▲47.  Vieira, E. et al., «Intermittent exposure of gravid rats to 1% nitrous oxide and the effect on the postnatal growth of their offspring.» South African Medical Journal. Vol. 53, p. 106-108. (1978). [AP-005346]
  • ▲48.  Pooler, N.L., Wisotzky, J. et Enlow, D.H., «Effect of nitrous oxide on palatal and craniofacial development in mice.» Journal of Dental Research. Vol. 60, p. 366. (1981).
  • ▲49.  Mullenix, P.J. et Moore, P., «Behavioral toxicity of nitrous oxide following prenatal exposure of rats.» Teratology. Vol. 31, no. 3, p. 5B. (1985). [AP-051198]
  • ▲50.  Mazze, R.I., Fujinaga, M. et Baden, J.M., «Reproductive and teratogenic effects of nitrous oxide, fentanyl and their combination in Sprague-Dawley rats.» British Journal of Anaesthesia. Vol. 59, p. 1291-1297. (1987). [AP-019883]
  • ▲51.  Land, P.C., Owen, E.L. et Linde, H.W., «Mouse sperm morphology following exposure to anesthetics during early spermatogenesis.» Anesthesiology. Vol. 51, no. 3, p. 5259. (1979). [AP-016672]
  • ▲52.  Ott, M. G., Diller, W. F. et Jolly, A. T., «Respiratory effects of toluene diisocyanate in the workplace: a discussion of exposure-response relationships.» Critical Reviews in Toxicology. Vol. 33, no. 1, p. 1-59. (2003). [AP-001046]
  • ▲53.  Kugel, G. et al., «Nitrous oxide and infertility.» Anesthesia Progress. Vol. 37, p. 176-180. (1990). [AP-051941]
  • ▲54.  Mazze, R.I. et al., «Germ cell studies in mice after prolonged exposure to nitrous oxide.» Toxicology and Applied Pharmacology. Vol. 67, p. 370-375. (1983). [AP-005342]
  • ▲55.  Wyrobek, A.J. et al., «Sperm studies in anesthesiologists.» Anesthesiology. Vol. 55, p. 527-532. (1981). [AP-050851]
  • ▲56.  Vieira, E. et Cleaton-Jones, P., «A study of spermatozoa from rats exposed to 0.5 % N2O.» Journal of Dental Research. Vol. 59, p. 947. (1980).
  • ▲57.  Greim, H., Occupational toxicants. Critical data evaluation for MAK values and classification of carcinogens.. Vol. 9. Weinheim : Wiley-vCH. (1991).
  • ▲58.  Kripke, B.J. et al., «Testicular reaction to prolonged exposure to nitrous oxide.» Anesthesiology. Vol. 44, p. 104-113. (1976).
  • ▲59.  Rice, S.A., Mazze, R.I. et Baden, J.M., «Effects of subchronic intermittent exposure to nitrous oxide in Swiss Webster mice.» Journal of Environmental Pathology, Toxicology and Oncology. Vol. 6, no. 2, p. 271-282. (1985). [AP-051939]
  • ▲60.  Rowland, A.S. et al., «Nitrous oxide and spontaneous abortion in female dental assistants.» American Journal of Epidemiology. Vol. 141, no. 6, p. 531-538. (1995). [AP-047584]
  • ▲61.  Cohen, E.N. et al., «Occupational disease among operating room personnel : a national study.» Anesthesiology. Vol. 41, p. 321-340. (1974).
  • ▲62.  Knill-Jones, R.P., Newman, B.J. et Spence, A..A., «Anaesthetic practice and pregnancy. Controlled study of male anaesthetists in the United Kingdom.» Lancet. Vol. 2, p. 807-809. (1975).
  • ▲63.  Kugel, G. et al., «Chronic low level nitrous oxide exposure and infertility.» Journal of Dental Research. Vol. 68, p. 313. (1989).
  • ▲64.  Friedler, G. et Meadows, M.E., «Paternal exposure to nitrous oxide : Effects on development of mouse offspring.» Abstract of neurotoxicology conference. Vol. 7, p. 365. (1987). [AP-051719]
  • ▲65.  Eger, E.I. et al., «A test of the carcinogenicity of enflurane, isoflurane, halothane, methoxyflurane, and nitrous oxide in mice.» Anesthesia and Analgesia. Vol. 57, p. 678-694. (1978).
  • ▲66.  Baden, J.M. et al., «Carcinogen bioassay of nitrous oxide in mice.» Anesthesiology. Vol. 64, p. 747-750. (1986).
  • ▲67.  Coate, W.B., Kapp, R.W. et Lewis, T.R., «Chronic exposure to low concentrations of halothane-nitrous oxide : lack of carcinogenic effect in the rat.» Anesthesiology. Vol. 50, p. 310-318. (1979).
  • ▲68.  IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, Overall evaluations of carcinogenicity : an updating of IARC monographs volumes 1-42. IARC monographs on the evaluation of carcinogenic risks to humans, Supplement 7. Lyon : International Agency for Research on Cancer. (1987). [MO-011531]   http://www.iarc.fr ou
    http://monographs.iarc.fr/
  • ▲69.  IARC Working Group on the Evaluation of Carcinogenic Risks of Chemical to Man, Cadmium, nickel, some epoxides, miscellaneous industrial chemicals and general considerations on volatile anaesthetics. IARC monographs on the evaluation of carcinogenic risks of chemical to man, Vol. 11. Lyon : International Agency for Research on Cancer. (1976). [MO-023436]   http://www.iarc.fr
  • ▲70.  American Conference of Governmental Industrial Hygienists, 2017 TLVs® and BEIs® : threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati (OH) : ACGIH. (2017). Publication 0114. [NO-003164]   http://www.acgih.org
  • ▲71.  Hoerauf, K.H. et al., «Sister chromatid exchange in human lymphocytes exposed to isoflurane and nitrous oxide in vitro.» British Journal of Anaesthesia. Vol. 82, no. 2, p. 268-270. (1999).
  • ▲72.  Yaws, C.L., Matheson gas data book. 7th ed. Parsippany, NJ : McGraw-Hill. (2001). [RS-415003]
  • ▲73.  Pohanish, R.P. et Greene, S.A., Wiley guide to chemical incompatibilities. 3ème éd. New Jersey : John Wiley & Sons Inc. (2009). [RR-015033]   www.wiley.com
  • ▲74.  Pohanish, R.P. et Greene, S.A., Hazardous materials handbook. New York (NY) : Van Nostrand Reinhold. (1996). [RR-515125]
  • ▲75.  Organisation internationale de normalisation, Gaz et mélanges de gaz : détermination du potentiel d'inflammabilité et d'oxydation pour le choix des raccords de sortie de robinets.. ISO: 10156:2010, 3e éd.. Genève : Organisation internationale de normalisation. (2010). [NO-001791]
  • ▲76.  Nations-Unies, «Partie 4 - Dispositions relatives à l'utilisation des emballages et des citernes - Liste des instructions d'emballage.» In: Recommandations relatives au transport des marchandises dangereuses - Règlement type - Dix-huitième édition révisée . New-York, N.Y. : United Nations. (2013). ST/SG/AC.10/1/rev. 18 (Vol. II). [MO-026856]   http://www.unece.org/fileadmin/DAM/trans/danger/publi/unrec/rev18/French/Rev18f_Volume2.pdf
    http://www.unece.org/fr/trans/danger/publi/unrec/rev18/18files_f.html
  • ▲77.  INRS, DEMETER : documents pour l'évaluation médicale des produits toxiques vis-à-vis de la reproduction. Paris : Institut national de recherche et de sécurité pour la prévention des accidents du travail et des maladies professionnelles. (2006).   www.inrs.fr
  • ▲78.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
    http://www.tc.gc.ca/tmd/menu.htm

La cote entre [ ] provient de la banque ISST du Centre de documentation de la CSST.