Phthalic anhydride

CAS Number : 85-44-9

WHMIS (Phthalic anhydride)

Workplace Hazardous Materials Information System

WHMIS 1988 classification - Note to reader
Update: 2005-06-23
  • WHMIS pictogram :

    D2A, D2B

D2A
  • Very Toxic Material Causing Other Toxic Effects 1 2
  • respiratory tract sensitization in humans
D2B
  • Toxic Material Causing Other Toxic Effects 3 4
  • skin sensitization in animals; eye irritation in animals

Disclosure at 0,1% according to the Ingredient disclosure list

WHMIS 2015 classification - Note to reader
Update: 2015-08-18

  • Acute toxicity - oral - Category 45 6
  • Serious eye damage/eye irritation - Category 25 6 7 8 9
  • Respiratory sensitization - Category 15 7 8
  • Skin sensitization - Category 1A5 6 7 8
  • Specific target organ toxicity - single exposure (respiratory tract irritation) - Category 3 - Respiratory tract irritation7 8

  • GHS pictogram : Exclamation mark

  • GHS pictogram : Health hazard

Warning

Harmful if swallowed (H302)
Causes serious eye irritation (H319)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
May cause respiratory irritation (H335)

Ingredient disclosure

References

  • ▲1.  Wernfors, M. et al., «Phthalic anhydride-induced occupational asthma.» International Archives of Allergy and Applied Immunology. Vol. 79, p. 77-82. (1986). [AP-012224]
  • ▲2.  Maccia, C.A. et al., «In vitro demonstration of specific IgE in phthalic anhydride hypersensitivity.» American Review of Respiratory Disease. Vol. 113, no. 5, p. 701-704. (1976). [AP-044461 ]
  • ▲3.  Basketter, D.A. et Scholes, E.W., «Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens.» Food and Chemical Toxicology. Vol. 30, no. 1, p. 65-69. (1992).
  • ▲4.  Gad, S.C., Walsh, R.D. et Dunn, B.J., «Correlation of ocular and dermal irritancy of industrial chemicals .» Journal of Toxicology : Cutaneous and Ocular Toxicology. Vol. 5, no. 3, p. 195-213. (1986). [AP-024825]
  • ▲5.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲6.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  • ▲7.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲8.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 38 : Anhydride phtalique. Cahiers de notes documentaires. Paris : INRS. (2004). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_38
  • ▲9.  Grant, W.M. et Schuman, J.S., Toxicology of the eye : effects on the eyes and visual systems from chemicals, drugs, metals and minerals, plants, toxins and venoms; also, systemic side effects from eye medications. Vol. 2, 4éme éd. Springfield, ILL : Charles C. Thomas. (1993). [RM-515030]

The [number] refers to the ISST database of the CSST Documentation Center.