Maleic anhydride

CAS Number : 108-31-6

WHMIS (Maleic anhydride)

Workplace Hazardous Materials Information System

WHMIS 1988 classification - Note to reader
Update: 2002-05-02
  • WHMIS pictogram : Skull and crossbones

    D1B, D2A, D2B

  • WHMIS pictogram : Corrosion

    E

D1B
  • Toxic Material Causing Immediate and Serious Toxic Effects 1
  • acute lethality: LD50 oral (guinea pig) = 390 mg/kg
D2A
  • Very Toxic Material Causing Other Toxic Effects 2 3 4 5 6 7
  • respiratory tract sensitization in humans
D2B
  • Toxic Material Causing Other Toxic Effects 8 9 10
  • skin sensitization in animals
E
  • Corrosive Material 11
  • Transportation of Dangerous Goods: class 8

Disclosure at 0,1% according to the Ingredient disclosure list

WHMIS 2015 classification - Note to reader
Update: 2015-10-23

  • Acute toxicity - oral - Category 412 13 14
  • Skin corrosion/irritation - Category 113 14 15
  • Serious eye damage/eye irritation - Category 114 16
  • Respiratory sensitization - Category 1A2 3 4 6 14
  • Skin sensitization - Category 1A8 9 10 14
  • Combustible dusts - See comments below17 18 19
  • Health hazards not otherwise classified (corrosion) - Category 1

  • GHS pictogram : Exclamation mark

  • GHS pictogram : Corrosion

  • GHS pictogram : Health hazard

Danger

Harmful if swallowed (H302)
Causes severe skin burns and eye damage (H314)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
Causes severe damage to the respiratory tract

Ingredient disclosure

Comments: This product could belong to the hazard class "Combustible dust", based on various factors related to the combustibility and explosiveness of its dust, including composition, shape and size of the particles.

References

  • ▲1.  Izmerov, N.F., Sanotsky, I.V. et Sidorov, K.K., Toxicometric parameters of industrial toxic chemicals under single exposure. Moscou : Centre of International Projects, GKNT. (1982). [MO-005528]
  • ▲2.  Topping, M.D. et al., «Specificity of the human IgE response to inhaled acid anhydrides.» Journal of Allergy and Clinical Immunology. Vol. 77, no. 6, p. 834-842. (1986). [AP-021035]
  • ▲3.  Baur, X. et al., «A clinical and immunological study on 92 workers occupationally exposed to anhydrides.» International Archives of Occupational and Environmental Health. Vol. 67, no. 6, p. 395-403. (1995). [AP-048750]
  • ▲4.  Venables, K.M., «Low molecular weight chemicals, hypersensitivity, and direct toxicity: the acid anhydrides.» British Journal of Industrial Medicine. Vol. 46, p. 222-232. (1989). [AP-025649]
  • ▲5.  Motolese, A. et al., «Contact dermatitis and contact sensitization among enamellers and decorators in the ceramics industry.» Contact Dermatitis. Vol. 28, no. 2, p. 59-62. (1993). [AP-053377]
  • ▲6.  Graneek, B.J. et al., «Occupational asthma caused by maleic anhydride bronchial provocation testing and immunological data.» Thorax. Vol. 41, no. 3, p. 251. (1986). [AP-018977]
  • ▲7.  Durham, S.R. et al., «The temporal relationship between increases in airway responsiveness to histamine and late asthmatic responses induced by occupational agents.» Journal of Allergy and Clinical Immunology. Vol. 79, no. 2, p. 398-406. (1987). [AP-021036]
  • ▲8.  Welinder, H. et al., «Strucutre-activity relationships of organic acid anhydrides as antigens in an animal model.» Toxicology. Vol. 103, no. 2, p. 127-136. (1995). [AP-041996]
  • ▲9.  Nakamura, Y. et al., «A quantitative comparison of induction and challenge concentrations inducing a 50% positive response in three skin sensitization tests : the guinea pig maximization test, adjuvant and patch test and Buehler test.» Journal of Toxicological Sciences. Vol. 24, no. 2, p. 123-131. (1999). [AP-061273]
  • ▲10.  Stevens, M.A., «Use of the albino guinea-pig to detect the skin-sensitizing ability of chemicals.» British Journal of Industrial Medicine. Vol. 24, p. 189-202. (1967). [AP-024848]   http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1008581/pdf/brjindmed00119-0021.pdf
  • ▲11.  Canada. Ministère des transports, Règlement sur le transport des marchandises dangereuses. Ottawa : Éditions du gouvernement du Canada. (2014). [RJ-410222]   http://www.tc.gc.ca/fra/tmd/clair-menu-497.htm
    http://www.tc.gc.ca/tmd/menu.htm
  • ▲12.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲13.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.   http://echa.europa.eu/information-on-chemicals/registered-substances
  • ▲14.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲15.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 205 : Anhydride maléique. Cahiers de notes documentaires. Paris : INRS. (2004). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_205
  • ▲16.  National Institute for Occupational Safety and Health, RTECS (Registry of Toxic Effects of Chemical Substances). Hamilton (Ont) : Canadian Centre for Occupational Health and Safety.   http://ccinfoweb.ccohs.ca/rtecs/search.html
  • ▲17.  Vincoli, J.W., Risk management for hazardous chemicals : G-Z. Vol. 2. Boca Raton : Lewis Publishers. (1997). [RM-515112]
  • ▲18.  BGIA-Gestis, Information system on hazardous substances of the Berufsgenossenschaften. Sankt Augustin, Germany : Berufsgenossenschaftliches Institut.   http://www.hvbg.de/e/bia/fac/stoffdb/index.html
  • ▲19.  National Fire Protection Association, Fire protection guide to hazardous materials. 14th ed. Quincy, Mass. : NFPA. (2010). [RR-334001]

The [number] refers to the ISST database of the CSST Documentation Center.