Trimellitic anhydride

CAS Number : 552-30-7

WHMIS (Trimellitic anhydride)

Workplace Hazardous Materials Information System

WHMIS 1988 classification - Note to reader
Update: 2005-09-26
  • WHMIS pictogram :

    D2A, D2B

  • Very Toxic Material Causing Other Toxic Effects 1 2 3 4
  • respiratory tract sensitization in humans
  • Toxic Material Causing Other Toxic Effects 5 6 7
  • skin sensitization in animals; eye irritation in animals

Disclosure at 0,1% according to the Ingredient disclosure list

WHMIS 2015 classification - Note to reader
Update: 2015-10-08

  • Serious eye damage/eye irritation - Category 18 9 10
  • Respiratory sensitization - Category 1A9 10 11
  • Skin sensitization - Category 1B6 8 9 11 12
  • Specific target organ toxicity - single exposure (respiratory tract irritation) - Category 3 - Respiratory tract irritation9 11 12
  • Combustible dusts - See comments below13 14

  • GHS pictogram : Corrosion

  • GHS pictogram : Health hazard

  • GHS pictogram : Exclamation mark


Causes serious eye damage (H318)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
May cause respiratory irritation (H335)

Ingredient disclosure

Comments: This product could belong to the hazard class "Combustible dust", based on various factors related to the combustibility and explosiveness of its dust, including composition, shape and size of the particles.


  • ▲1.  Bernstein, D.I., Patterson, R. et Zeiss, C.R., «Clinical and immunologic evaluation of trimellitic anhydride and phthalic anhydride exposed workers using a questionnaire with comparative analysis of enzyme-linked immunosorbent and radioimmunoassay studies.» Journal of Allergy and Clinical Immunology. Vol. 69, no. 3, p. 311-318. (1982). [AP-022699]
  • ▲2.  Bernstein, D.I. et al., «The relationship of total serum IgE and blocking antibody in trimellitic anhydride-induced occupational asthma.» Journal of Allergy and Clinical Immunology. Vol. 72, no. 6, p. 714-719. (1983). [AP-006128]
  • ▲3.  Zeiss, R. et al., «Syndromes in workers exposed to trimellitic anhydride. A longitudinal clinical and immunologic study..» Annals of Internal Medicine. Vol. 98, no. 1, p. 8-12. (1983). [AP-001166]
  • ▲4.  Zeiss, C.R. et al., «A clinical and immunologic study of employees in a facility manufacturing trimellitic anhydride.» Allergy Proceedings. Vol. 13, no. 4, p. 193-198. (1992). [AP-050830]
  • ▲5.  American Conference of Governmental Industrial Hygienists, 2010 TLVs and BEIs with 7th edition documentation CD-ROM. Cincinnati, OH : ACGIH. (2010). Publication 0111CD. [CD-120061]
  • ▲6.  Basketter, D.A. et Scholes, E.W., «Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens.» Food and Chemical Toxicology. Vol. 30, no. 1, p. 65-69. (1992).
  • ▲7.  Amoco Corporation, 13-week inhalation toxicity study of trimellitic anhydride in rats (final report) with attachments and cover letter dated 030888. (1988). Microfiche : OTS0513426-1, EPA/OTS; Doc #89-880000210
  • ▲8.  ECHA (European Chemicals Agency) , Information on Chemicals (REACH). Helsinki, Finland.
  • ▲9.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety
  • ▲10.  OECD, «TRIMELLITIC ANHYDRIDE & TRIMELLITIC ACID CAS N°: 552-30-7; 528-44-9.» In: OECD Screening Information Data Set (SIDS) for High Production Volume Chemicals. UNEP PUBLIC. (2002).
  • ▲11.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]
  • ▲12.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 172 : Anhydride trimellitique. Cahiers de notes documentaires. Paris : INRS. (2004). [RE-005509]
  • ▲13.  Dutch Institute for the Working Environment et Dutch Chemical Industry Association, Chemical safety sheets : working safely with hazardous chemicals. Netherlands : Kluwer Academic Publishers. (1991). [RR-015010]
  • ▲14.  BGIA-Gestis, Information system on hazardous substances of the Berufsgenossenschaften. Sankt Augustin, Germany : Berufsgenossenschaftliches Institut.

The [number] refers to the ISST database of the CSST Documentation Center.