WHMIS (Isophorone diisocyanate)

Workplace Hazardous Materials Information System

WHMIS 1988 classification - Note to reader
Update: 2000-09-28
  • WHMIS pictogram : Skull and crossbones

    D1A, D2A, D2B

D1A
  • Very Toxic Material Causing Immediate and Serious Toxic Effects 1
  • acute lethality: LC50 inhalation/4 hours (rat) =123 mg/m³
D2A
  • Very Toxic Material Causing Other Toxic Effects 2 3 4
  • respiratory tract sensitization in humans
D2B
  • Toxic Material Causing Other Toxic Effects 1 2 5 6 7
  • eye irritation in animals; skin irritation in animals; skin sensitization in humans

Disclosure at 0,1% according to the Ingredient disclosure list

WHMIS 2015 classification - Note to reader
Update: 2017-03-14

  • Acute toxicity - inhalation - Category 1
  • Skin corrosion/irritation - Category 28 9 10
  • Serious eye damage/eye irritation - Category 28 9 10
  • Respiratory sensitization - Category 19 10
  • Skin sensitization - Category 18 9
  • Specific target organ toxicity - single exposure (respiratory tract irritation) - Category 3 - Respiratory tract irritation9 10

  • GHS pictogram : Skull and crossbones

  • GHS pictogram : Health hazard

  • GHS pictogram : Exclamation mark

Danger

Fatal if inhaled (H330)
Causes skin irritation (H315)
Causes serious eye irritation (H319)
May cause allergy or asthma symptoms or breathing difficulties if inhaled (H334)
May cause allergic skin reaction (H317)
May cause respiratory irritation (H335)

References

  • ▲1.  Kimmerle, G., Isophorone diisocyanate : Toxicological studies. Report no. 908. Wuppertal-Elberfeld : Farbenfabriken Bayer AG, Institute fuer Toxikologie. (1968). Microfiche : OTS0528418
  • ▲2.  American Conference of Governmental Industrial Hygienists, 2010 TLVs and BEIs with 7th edition documentation CD-ROM. Cincinnati, OH : ACGIH. (2010). Publication 0111CD. [CD-120061]   http://www.acgih.org
  • ▲3.  Tyrer, F.H., «Hazards of spraying with two-pack paints containing isocyanates.» Journal of the Society of Occupational Medicine. Vol. 29, p. 22-24. (1979). [AP-008629]
  • ▲4.  Bernstein, D. et al., Asthma in the workplace. 2nd ed. New York : Marcel Dekker. (1999 ). [MO-002878]
  • ▲5.  Estlander, T. et al., «Occupational dermatitis from exposure to polyurethane chemicals.» Contact dermatitis. Vol. 27, p. 161-165. (1992).
  • ▲6.  Rothe, von A., «Zur Frage arbeitsbedingter Hautschädigungen durch Polyurethanchemikalien.» Berufs Dermatosen. Vol. 24, no. 1, p. 7-24. (1976). [AP-019989]
  • ▲7.  Lachapelle, J.M. et Lachapelle-Ketelaer, M.J., «Cross-sensitivity between isophorone diamine (IPD) and isophorone diisocyanate (IPDI).» Contact Dermatitis. Vol. 5, p. 55. (1979). [AP-023691]
  • ▲8.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org
  • ▲9.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲10.  France. Institut national de recherche et de sécurité, Fiche toxicologique no 166: Diisocyanate d'isophorone. Cahiers de notes documentaires. Paris : INRS. (2009). [RE-005509]   http://www.inrs.fr/publications/bdd/fichetox.html
    http://www.inrs.fr/publications/bdd/fichetox/fiche.html?refINRS=FICHETOX_166

The [number] refers to the ISST database of the CSST Documentation Center.