The section entitled Complete data sheet is not available in English for this substance. Consult the French version.

Identification

Description


Formule moléculaire brute : C5H8O2

Principaux synonymes

Noms français :

  • 1,3-Diformal propane
  • 1,3-Diformylpropane
  • 1,5-Pentanedione
  • Aldéhyde glutarique
  • Glutaral
  • Glutaraldéhyde
  • Glutardialdéhyde
  • Glutaric acid dialdehyde
  • Glutaric aldehyde
  • Glutarol
  • Pentanedial
  • Pentanedial-1,5

Noms anglais :

  • 1,5-Pentanedial
  • Glutaraldehyde
  • Glutaraldehyde, activated or inactivated
  • Glutaric dialdehyde
Famille chimique
  • Aldéhyde
Commentaires

Le glutaraldéhyde est très rarement vendu ou utilisé sous forme pure. Généralement, on le trouve en solution aqueuse dont la concentration varie entre 1 et 50 %. Ces solutions commerciales contiennent habituellement un stabilisant en faible concentration (ex. méthanol, entre 0,05 et 0,5 %), pour ralentir la polymérisation graduelle du glutaraldéhyde.

Utilisation et sources d'émission

Le glutaraldéhyde est utilisé dans les secteurs médical et dentaire

  • comme agent désinfectant (les solutions aqueuses à 2 % sont utilisées pour la stérilisation à froid des instruments)
  • dans les solutions de développement de films de rayons -X  (solutions aqueuses 0,5 à 1 %)
  • comme fixateur de matériel biologique (solutions aqueuses de 3 % à 8 %)
  • comme agent thérapeutique (solutions aqueuses à 2 %, 10 % et 25 % utilisées dans le traitement contre la transpiration excessive, les infections fongiques, les verrues).

Il est également utilisé dans le secteur industriel

  • comme agent de tannage du cuir
  • comme agent de conservation en thanatopraxie (embaumement)
  • comme intermédiaire chimique de la fabrication des adhésifs et de matériel électrique
  • comme biocide dans les boues de forage, les conduites d'huile et de gaz ainsi que dans les procédés de traitements des eaux de refroidissement industrielles
  • comme agent de conservation de plusieurs produits chimiques tels que les adoucisseurs et les cosmétiques.

Références

  • ▲1.  Beije, B. et Lundberg, P., DECOS and NEG basis for an occupational standard : glutaraldehyde. Arbete och Hälsa , Vol. 20. Solna, Suède : Arbetslivinstitutet. (1997). [MO-127539 ]   https://gupea.ub.gu.se/dspace/handle/2077/3194?locale=en
  • ▲3.  O’Neil, M.J., Smith, A. et Heckelman, P.E., The Merck index : an encyclopedia of chemicals, drugs, and biologicals. 13th ed. Cambridge, MA : Cambridge Soft; Merck & CO. (2001). [RM-403001]
  • ▲5.  Drolet, D. et Beauchamp, G, Guide d'échantillonnage des contaminants de l'air en milieu de travail. Études et recherches / Guide technique, 8ème éd. revue et mise à jour. Montréal : IRSST. (2012). T-06. [MO-220007]   http://www.irsst.qc.ca
    http://www.irsst.qc.ca/files/documents/PubIRSST/t-06.pdf
  • ▲9.  American Conference of Governmental Industrial Hygienists, 2010 TLVs and BEIs with 7th edition documentation CD-ROM. Cincinnati, OH : ACGIH. (2010). Publication 0111CD. [CD-120061]   http://www.acgih.org
  • ▲10.  Beauchamp, R.O. et al., «A critical review of the toxicology of glutaraldehyde », Critical Reviews in Toxicology, 22, 3, 1992, 143-174 [AP-038636]
  • ▲11.  Ballantyne, B. et Union Carbide, Toxicology of glutaraldehyde : review of studies and human health effects. Danbury, CT : Union Carbide. (1995). [MO-019170]
  • ▲12.  Ballantyne, B. et McKelvey, J.A., «Percutaneous pharmacokinetics and material balance studies with glutaraldehyde», Journal of Toxicology : Cutaneous and Ocular Toxicology, 11, 4, 1992, 341-367
  • ▲13.  Ballantyne, B. et Jordan, S.L., «Toxicological, medical and industrial hygiene aspects of glutaraldehyde with particular reference to its biocidal use in cold sterilization procedures.» Journal of Applied Toxicolcology. Vol. 21, no. 2, p. 131-151. (2001).
  • ▲14.  Smyth, H.F. et al., «Range-finding toxicity data : List VI.» American Industrial Hygiene Association Journal. Vol. 23, p. 95-107. (1962). [AP-041987]
  • ▲15.  Rietschel, R.L. et Fowler, Jr., J.F., Fisher's contact dermatitis. 5ème. Philadelphia : Lippincott Williams & Wilkins. (2001). [RM-015084]
  • ▲16.  Ballantyne, B. et Myers, R.C., «The acute toxicity and primary irritancy of glutaraldehyde solutions.» Veterinary and Human Toxicology. Vol. 43, no. 4, p. 193-202. (2001).
  • ▲17.  Zissu, D., Évaluation des effets du glutaraldéhyde sur la santé en milieu professionnel. Cahiers de notes documentaires - Hygiène et sécurité du travail. INRS. (1999).   http://www.inrs.fr/htm/evaluation_effets_glutaraldehyde_sur_la_sante_en.html
  • ▲18.  Connaughton, P., «Occupational exposure to glutaraldehyde associated with tachycardia and palpitations.» The Medical Journal of Australia. Vol. 159, p. 567. (1993).
  • ▲19.  Shaffer, M.P. et Belsito, D.V., «Allergic contact dermatitis from glutaraldehyde in health-care workers.» Contact Dermatitis. Vol. 43, no. 3, p. 150-156. (2000).
  • ▲20.  Foussereau, J., Cavelier, C. et Zissu, D., «L'allergie de contact professionnelle aux antiseptiques aldéhydés en milieu hospitalier.» Archives des maladies professionnelles, de médecine du travail et de sécurité sociale. Vol. 53, no. 5, p. 325-338. (1992). [AP-039379]
  • ▲21.  Bernstein, D. et al., Asthma in the workplace. 2nd ed. New York : Marcel Dekker. (1999 ). [MO-002878]
  • ▲22.  Nicewicz, J. T. et al., «Occupational asthma caused by glutaraldehyde exposure», Immunology & allergy practice, 8, 8, 1986, 272-278 [AP-050825]
  • ▲23.  Holness, D.L. et Nethercott, J.R., «Contact Dermatitis in funeral service workers.» Contact Dermatitis. Vol. 18, no. 5, p. 263-267. (1988). [AP-022255]
  • ▲24.  Goncalo, S. et al., «Occupational contact dermatitis to glutaraldehyde.» Contact Dermatitis. Vol. 10, no. 3, p. 183-184. (1984). [AP-048004]
  • ▲25.  McMurren, T. et Chan-Yeung, M., «Occupational asthma in a technologist exposed to glutaraldehyde.» Journal of Allergy and Clinical Immunology. Vol. 91, no. 5, p. 974-978. (1993). [AP-047995]
  • ▲26.  Beach, J. R. et al., «Glutaraldehyde , asthma and work : a cautionary tale.» Occupational Medicine. Vol. 44, no. 2, p. 95-98. (1994). [AP-044768]
  • ▲27.  Burge, P.S., Curran, A.D. et Wiley, K., «Clinical and immunologic evaluation of workers exposed to glutaraldehyde.» Allergy. Vol. 51, p. 826-832. (1996). [AP-058233]
  • ▲28.  Corrado, O.J., Osman, J. et Davies, R.J., «Asthma and rhinitis after exposure to glutaraldehyde in endoscopy units.» HumanToxicology. Vol. 5, p. 325-328. (1986). [AP-025224]
  • ▲29.  Marzulli, F.N. et Maibach, H.I., «The use of graded concentrations in studying skin sensitizers : experimental contact sensitiziation in man.» Food and Cosmetics Toxicology. Vol. 12, p. 219-227. (1974). [AP-026418]
  • ▲30.  Holness, D.L., Nethercott, J.R. et Page, E., «Occupational contact dermatitis due to glutaraldehyde in health care workers.» Contact Dermatitis. Vol. 18, p. 193-196. (1988). [AP-019005]
  • ▲31.  Gannon, P.F.G. et al., «Occupational asthma due to glutaraldehyde and formaldehyde in endoscopy and X-ray departments.» Thorax. Vol. 50, p. 156-159. (1995). [AP-060591]
  • ▲32.  Curran, A.D., Burge, P.S. et Wiley, K., «Clinical and immunologic evaluation of workers exposed to glutaraldehyde.» Allergy. Vol. 51, no. 11, p. 826-832. (1996). [AP-058233]
  • ▲33.  Jachuck, S.J. et al., «Occupational hazard in hospital staff exposed to 2 percent glutaraldehyde in an endoscopy unit.» Journal of the Society of Occupational Medicine. Vol. 39, no. 2, p. 69-71. (1989).
  • ▲34.  Hamann, C.P., Rodgers, P.A. et Sullivan, K., «Allergic contact dermatitis in dental professionals : effective diagnosis and treatment.» Journal. American Dental Association. Vol. 134, no. 2, p. 185-194. (2003).
  • ▲35.  Di Stefano, F. et al., «Glutaraldehyde : an occupational hazard in the hospital setting.» Allergy. Vol. 54, p. 1105-1109. (1999).
  • ▲36.  Azadi, S., Klink, K.J. et Meade, B.J., «Divergent immunological responses following glutaraldehyde exposure.» Toxicology and Applied Pharmacology. Vol. 197, p. 1-8. (2004).
  • ▲37.  Mc Donald, J.C., Keynes, H.L. et Meredith, S.K., «Reported incidence of occupational asthma in the United Kingdom, 1989-97.» Occupational and Environmental Medicine. Vol. 57, p. 823-829. (2000).
  • ▲38.  Anees, W., Robertson, A.S. et Burge, P.S., «Glutaraldehyde induced asthma in endoscopy nursing staff.» Occupational and Environmental Medicine. Vol. 58, p. 544-545. (2001).
  • ▲39.  Vyas, A. et al., «Survey of symptoms, respiratory function, and immunology and their relation to glutaraldehyde and other occupational exposures among endoscopy nursing staff.» Occupational and Environmental Medicine. Vol. 57, p. 752-759. (2000). [AP-058886]
  • ▲40.  Deutsche Forschungsgemeinschaft, MAK Value documentation: Glutaraldehyde. The MAK Collection for Occupational Health and Safety. (2002).   http://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb11130e3514/pdf
  • ▲41.  Zemtsov, A., «Evaluation of antigenic determinant in glutaraldehyde contact dermatitis by patch testing with chemically related substances», American Journal of Contact Dermatitis, 3, 3, 1992, 138-141
  • ▲42.  Ravis, S.M. et al., «Glutaraldehyde-induced and formaldehyde-induced allergic contact dermatitis among dental hygienists and assistants.» Journal. American Dental Association. Vol. 134, no. 8, p. 1072-1078. (2003).
  • ▲43.  Neeper-Bradley, T.L. et Ballantyne, B., «Two-generation reproduction study by dosing with glutaraldehyde in the drinking water of CD rats.» Journal of Toxicology and Environmental Health. Vol. 60, no. Part A, p. 107-129. (2000).
  • ▲44.  Ema, M., Itamit, T. et Kawasaki, H., «Teratological assessment of glutaraldeyde in rats by gastric intubation», Toxicology Letters, 63, 2, 1992, 147-153 [AP-040860]
  • ▲45.  Hemminki, K, Kyyronen, P. et Lindbohm, M.L, «Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs and other potential hazards in hospitals, based on registered information outcome.» Journal of Epidemiology and Community Health. Vol. 39, p. 141-147. (1985). [AP-010898 ]
  • ▲46.  Hemminki, K. et al., «Spontaneous abortions in hospital staff engaged in sterilising instruments with chemical agents.» British Medical Journal. Vol. 285, p. 1461-1463. (1982). [AP-121545 ]
  • ▲47.  Overman, D.O., «Testing for percutaneous embryotoxicity of laboratory reagents in the hamster.» Teratology. Vol. 23, no. 2, p. 56A. (1981). [AP-041416]
  • ▲48.  «Final report on the safety assessment of glutaral.» Journal of the American College of Toxicology. Vol. 15, no. 2, p. 98-139. (1996).
  • ▲49.  van Birgelen, Angélique P.J.M. et al., «Effects of glutaraldehyde in a 2-year inhalation study in rats and mice.» Toxicological Sciences. Vol. 55, p. 195-205. (2000).
  • ▲50.  Van Miller, J.P. et al., «Chronic toxicity and oncogenicity study with glutaraldehyde dosed in the drinking water of Fischer 344 rats.» Toxicology. Vol. 175, no. 1-3, p. 177-189. (2002).
  • ▲51.  American Conference of Governmental Industrial Hygienists, 2017 TLVs® and BEIs® : threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati (OH) : ACGIH. (2017). Publication 0114. [NO-003164]   http://www.acgih.org
  • ▲52.  Mirsalis, J.C. et al., «Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment : testing of 24 compounds.» Environmental and Molecular Mutagenesis. Vol. 14, no. 3, p. 155-164. (1989). [AP-027663]
  • ▲53.  Bremudez, E. et al., «Evaluation of the genotoxic potential of glutaraldehdye.» Environmental and Molecular Mutagenesis. Vol. 18, p. 113-119. (1991). [AP-035984]
  • ▲54.  Loh, E., Mirsalis, J. et Tyson, K, «Induction of unscheduled DNA synthesis (UDS) AND cell proliferation in mouse and rat hepatocytes following in vivo treatment.» Environmental Mutagenesis. Vol. 7, no. 3. (1985). [AP-048008]
  • ▲55.  Slesinski, R.S. et al., «Mutagenicity evaluation of glutaraldehyde in a battery of in vitro bacterial and mammalian test systems», Food and Chemical Toxicology, 21, 5, 1983, 621-629 [AP-005758]
  • ▲56.  McGregor, D.B. et al., «Responses of the L5178Y TK+/TK-mouse lymphoma cell forward mutation assay II : 18 coded chemicals.» Environmental and Molecular Mutagenesis. Vol. 11, p. 91-118. (1988). [AP-041493 ]
  • ▲57.  Archer, P. et al., «Development of a standard protocol for in vitro cytogenetic testing with chinese hamster ovary cells : comparison of results for 22 compounds in two laboratories..» Environmental Mutagenesis. Vol. 7, p. 1-51. (1985). [AP-046293]
  • ▲58.  Letter from BASF Corp to USA EPA submitting preliminary results of prenatal toxicity study with glutaraldehyde.. (1990). Microfiche : OTS0526410-1, 8EHQ-1290-1008
  • ▲59.  NTP technical report on the toxicology and carcinogenesis studies of glutaraldehyde (cas no. 111-30-8) in F344/rats... (inhalation studies). (1999). Microfiche : PB2000-101418
  • ▲60.  Vergnes, J.S. et Ballantyne, B., «Genetic toxicology studies with glutaraldehyde.» Journal of Applied Toxicology. Vol. 22, no. 1, p. 45-60. (2002).
  • ▲61.  Tamada, M. et al., «Mutagenicity of glutaraldehyde in mice.» Bokin Bobbai (Journal of antibacterial and antifungal agents). Vol. 6, no. 2, p. 62. (1978). [AP-048264]
  • ▲62.  OECD, «Glutaraldehyde CAS N° : 111-30-8.» In: OECD Screening Information Data Set (SIDS) for High Production Volume Chemicals. Paris : UNEP Publications. (2005).   http://www.inchem.org/documents/sids/sids/111308.pdf
  • ▲63.  Centre canadien d'hygiène et de sécurité au travail, CHEMINFO, Hamilton, Ont. : Canadian Centre for Occupational Health and Safety   http://ccinfoweb.ccohs.ca/cheminfo/search.html
  • ▲64.  American Conference of Governmental Industrial Hygienists, Documentation of the threshold limit values and biological exposure indices / Documentation of TLV's and BEI's. 7th ed. Cincinnati, Ohio : ACGIH. (2001-). Publication #0100Doc. [RM-514008]   http://www.acgih.org

La cote entre [ ] provient de la banque ISST du Centre de documentation de la CSST.